Effects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation

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dc.contributor.authorOzbilgin M.K.
dc.contributor.authorKaraman G.Z.
dc.contributor.authorGencur S.
dc.contributor.authorGumustepe E.
dc.contributor.authorKurtman C.
dc.date.accessioned2024-07-22T08:07:19Z
dc.date.available2024-07-22T08:07:19Z
dc.date.issued2020
dc.description.abstractBackground: Adrenomedullin (AM) and its receptor, receptor actvity-modifying protein (RAMP) 2 have pleiotropic regulatory functons in normal tssue and cancer tssue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investgate a possible role of AM and RAMP2 in the radiaton exposure in the normal lung tssue. M aterial s and Methods: Four groups with 6 male adult Swiss Albino mice per group were investgated. The mice were subjected to a 500 cGy single-dose radiaton exposure in the total body radiaton device and lung tssues were collected. 1, 2, and 7 days after radiaton exposure, with 1 reference group which was not exposed to radiaton. Results: The general histology and the immunohistochemistry of the tssue samples prepared with ant-AM, ant-RAMP2, and monoclonal antbodies were investgated, yielding a statstcally significant increase for AM on day 3 and for RAMP2 on day 1 after radiaton exposure. Conclusion: The observed increase of AM and RAMP2 concentratons in the normal tssue matrix after radiaton exposure may play a role in the side effects of radiotherapy. © 2020 Novin Medical Radiation Institute. All rights reserved.
dc.identifier.DOI-ID10.18869/acadpub.ijrr.18.3.571
dc.identifier.issn23223243
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13921
dc.language.isoEnglish
dc.publisherNovin Medical Radiation Institute
dc.subjectadrenomedullin
dc.subjectketamine
dc.subjectmonoclonal antibody
dc.subjectreceptor activity modifying protein 2
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectconnective tissue
dc.subjectcontrolled study
dc.subjectfibroblast
dc.subjecthistology
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectlung injury
dc.subjectlung parenchyma
dc.subjectmacrophage
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectradiation dose
dc.subjectradiation exposure
dc.subjectstroma cell
dc.subjectwhole body radiation
dc.titleEffects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation
dc.typeArticle

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