Gingival crevicular fluid and plasma acute-phase cytokine levels in different periodontal diseases

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dc.contributor.authorBecerik S.
dc.contributor.authorÖztürk V.O.
dc.contributor.authorAtmaca H.
dc.contributor.authorAtilla G.
dc.contributor.authorEmingil G.
dc.date.accessioned2024-07-22T08:19:15Z
dc.date.available2024-07-22T08:19:15Z
dc.date.issued2012
dc.description.abstractBackground: The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patientswith different periodontal diseases. Methods: Eighty individuals were included in this study; 20 with chronic periodontitis (CP), 20 with generalized aggressive periodontitis (GAgP), 20 with gingivitis, and 20 classified as healthy (H). Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. Plasma and GCF IL-1β, IL-6, IL-11, OSM, and LIF levels were analyzed by enzyme-linked immunosorbent assay. Results: CP and GAgP groups had significantly higher GCF IL-1β, IL-6, and IL-11 levels when compared with the H group (P <0.05). Conversely, GCF LIF levels of the CP and GAgP groups were lower than those of the H group (P <0.05). GCF OSM levels did not differ significantly among study groups. Plasma levels of all the cytokines studied were not significantly different among the study groups. Conclusions: Based on the present data, elevated IL-1β, IL-6, and IL-11 GCF levels, but not plasma levels, are suggested as reliable inflammatory biomarkers in periodontal diseases. Decreased LIF levels in diseased groups might reflect the possible beneficial effects of LIF in the modulation of inflammatory response in gingiva.
dc.identifier.DOI-ID10.1902/jop.2012.110616
dc.identifier.issn00223492
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17577
dc.language.isoEnglish
dc.subjectAcute-Phase Proteins
dc.subjectAdult
dc.subjectAggressive Periodontitis
dc.subjectBiological Markers
dc.subjectCase-Control Studies
dc.subjectChronic Periodontitis
dc.subjectCytokines
dc.subjectFemale
dc.subjectGingival Crevicular Fluid
dc.subjectGingivitis
dc.subjectHumans
dc.subjectInterleukin-11
dc.subjectInterleukin-1beta
dc.subjectInterleukin-6
dc.subjectLeukemia Inhibitory Factor
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOncostatin M
dc.subjectStatistics, Nonparametric
dc.subjectYoung Adult
dc.subjectacute phase protein
dc.subjectbiological marker
dc.subjectcytokine
dc.subjectinterleukin 11
dc.subjectinterleukin 1beta
dc.subjectinterleukin 6
dc.subjectleukemia inhibitory factor
dc.subjectLIF protein, human
dc.subjectoncostatin M
dc.subjectOSM protein, human
dc.subjectadult
dc.subjectaggressive periodontitis
dc.subjectarticle
dc.subjectblood
dc.subjectcase control study
dc.subjectchemistry
dc.subjectchronic periodontitis
dc.subjectfemale
dc.subjectgingivitis
dc.subjecthuman
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectnonparametric test
dc.titleGingival crevicular fluid and plasma acute-phase cytokine levels in different periodontal diseases
dc.typeArticle

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