Association of intra-tumoral tumour-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio is an independent prognostic factor in non-small cell lung cancer

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dc.contributor.authorDirican N.
dc.contributor.authorKarakaya Y.A.
dc.contributor.authorGunes S.
dc.contributor.authorDaloglu F.T.
dc.contributor.authorDirican A.
dc.date.accessioned2024-07-22T08:10:28Z
dc.date.available2024-07-22T08:10:28Z
dc.date.issued2017
dc.description.abstractBackground: Studies suggest that tumour-infiltrating lymphocytes (TILs) and inflammation markers have independent roles in non-small cell lung cancer (NSCLC), but the relationship between the two pronostic factors remains unclear. In this study, we investigated TILs and inflammation markers in with patients advanced stage NSCLC and assessed the association of their levels with prognosis. Materials and Methods: TILs were evaluated by immunohistochemical staining for cluster of differentiation 3 (CD3) and cluster of differentiation 5 (CD5) and by hematoxylin and eosin staining for non-specific lymphocyte. We investigated the localisation pattern of TILs in advanced stage NSCLC. We divided all cases into two groups: TILs-high and TILs-low groups, by 75th percentile of the population of. In our study, inflammation markers were assessed by C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR). Results: The results showed that the presence of intra-tumoral high CD3+ and low CD5+ were an independent prognostic factor for overall survival (respectively, P = 0.022 and P = 0.025). Moreover, the high NLR and serum high CRP levels were associated with poor survival (respectively, P = 0.008; P = 0.027). In multi-variate survival analysis, the high CD3+, low CD5+, high NLR, tumour node metastasis (TNM) stage, depth of tumour invasion and lymph node metastasis remained independent prognostic factors (respectively, P = 0.018, P = 0.020, P = 0.024, P = 0.038, P = 0.020 and P = 0.047).The high NLR was detected negative correlation with intra-tumoral CD3+ and positive correlation with intra-tumoral CD5+ (respectively, r = −0.623, P = 0.012; r = 0.628, P = 0.028). Conclusions: This study is first report demonstrating the prognostic value of intra-tumoral low CD5+ with NSCLC. Increased CD3+ and low CD5+ was observed in patients with poor prognosis; the two molecules were correlated with NLR, suggesting that inflammation might be used as improve therapeutic efficacy to immunotherapy for advanced NSCLC. © 2015 John Wiley & Sons Ltd
dc.identifier.DOI-ID10.1111/crj.12417
dc.identifier.issn17526981
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15253
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomarkers
dc.subjectC-Reactive Protein
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCD3 Complex
dc.subjectCD5 Antigens
dc.subjectFemale
dc.subjectHumans
dc.subjectInflammation
dc.subjectLung Neoplasms
dc.subjectLymphatic Metastasis
dc.subjectLymphocytes
dc.subjectLymphocytes, Tumor-Infiltrating
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Staging
dc.subjectNeutrophils
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectSurvival Analysis
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectCD3 antigen
dc.subjectCD5 antigen
dc.subjecteosin
dc.subjecthematoxylin
dc.subjectC reactive protein
dc.subjectadult
dc.subjectadvanced cancer
dc.subjectaged
dc.subjectArticle
dc.subjectcancer localization
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectcancer survival
dc.subjectCD3+ T lymphocyte
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease classification
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectinflammation
dc.subjectlymph node metastasis
dc.subjectmale
dc.subjectmiddle aged
dc.subjectneutrophil lymphocyte ratio
dc.subjectnon small cell lung cancer
dc.subjectoverall survival
dc.subjectpathology
dc.subjectpriority journal
dc.subjectsurvival prediction
dc.subjecttumor associated leukocyte
dc.subjecttumor invasion
dc.subjectvery elderly
dc.subjectcomparative study
dc.subjectimmunology
dc.subjectlung tumor
dc.subjectlymphocyte
dc.subjectmetabolism
dc.subjectmortality
dc.subjectneutrophil
dc.subjectnon small cell lung cancer
dc.subjectprognosis
dc.subjectretrospective study
dc.subjectsurvival analysis
dc.subjecttumor associated leukocyte
dc.titleAssociation of intra-tumoral tumour-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio is an independent prognostic factor in non-small cell lung cancer
dc.typeArticle

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