β2-microglobulin and cystatin C in type 2 diabetes

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dc.contributor.authorAksun, SA
dc.contributor.authorÖzmen, D
dc.contributor.authorÖzmen, B
dc.contributor.authorParildar, Z
dc.contributor.authorMutaf, I
dc.contributor.authorTurgan, N
dc.contributor.authorHabif, S
dc.contributor.authorKumanliogluc, K
dc.contributor.authorBayindir, O
dc.date.accessioned2025-04-10T10:32:38Z
dc.date.available2025-04-10T10:32:38Z
dc.description.abstractBackground: Changes in glomerular filtration rate (GFR) provide a valuable indicator of the progression of diabetic nephropathy (DN). This study was designed to demonstrate the clinical values of serum cystatin C (Cys C) and beta2-microglobulin in the assessment of renal function in type 2 diabetics by comparing them with the GFR, estimated from the uptake phase of 99 in technetium dimetiltriamino pentaacetic acid renogram (GFR-DTPA) and creatinine clearances. Materials and Methods: 68 type 2 diabetic patients with (urinary albumin excretions (UAE) 30-300 mg/24h) (n = 39) and without (UAE <30mg/24h) (n = 29) microalbuminuria and 32 controls were enrolled in the study. Serum Cys C, beta2-microglobulin, creatinine, urinary microalbumin levels, creatinine clearances and GFR-DTPA values were determined in all groups. Nonparametric ROC curves, using a cut-off GFR-DTPA of 60 mL/min/ 1.73 m(2), were obtained for these markers. Results: Serum Cys C, beta2-microglobulin, glucose and HbA1c concentrations were significantly higher in the group with diabetes compared to controls. In the patients with microalbuminuria, serum Cys C and glucose concentrations increased significantly in comparison to patients with normoalbuminuria, while no differences were observed for beta2-microglobulin levels. Serum creatinine concentrations, GFR-DTPA values and creatinine clearances were not different between both diabetic groups and controls. Cys C was positively correlated with beta2-microglobulin and creatinine and negatively with GFR values; beta2-microglobulin was also positively correlated with serum creatinine in microalbuminurics. A significant inverse correlation was found between beta2-microglobulin and GFR values in both microalbuminurics and normoalbuminurics. Conclusions: Increased Cys C and beta2-microglobulin in diabetics may be early indicators of incipient DN. The diagnostic accuracies of Cys C and beta2-microglobulin are superior to that of serum creatinine in distinguishing between mild and moderately reduced GFR.
dc.identifier.e-issn1439-3646
dc.identifier.issn0947-7349
dc.identifier.urihttp://hdl.handle.net/20.500.14701/39011
dc.language.isoEnglish
dc.titleβ2-microglobulin and cystatin C in type 2 diabetes
dc.typeArticle

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