Radiological findings based comparison of functional status in patients who have post-covid lung injury or idiopathic pulmonary fibrosis

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dc.contributor.authorKızılırmak D.
dc.contributor.authorSarı S.
dc.contributor.authorCan F.
dc.contributor.authorHavlucu Y.
dc.date.accessioned2024-07-22T08:02:08Z
dc.date.available2024-07-22T08:02:08Z
dc.date.issued2023
dc.description.abstractBackground: Following COVID-19 infection, some patients acquired lung injury and fibrosis. Idiopathic pulmonary fibrosis is characterized by lung fibrosis. Both post-COVID lung injury and idiopathic pulmonary fibrosis cause loss of respiratory function and involvement of the lung parenchyma. We aimed to compare respiratory related functional characteristics and radiological involvement between post-COVID lung injury and idiopathic pulmonary fibrosis. Methods: A single center, cross-sectional study was applied. Patients with post-COVID lung injury and idiopathic pulmonary fibrosis included in the study. All patients underwent the 6-minute walk test, as well as the Borg and MRC scales. Radiological images were evaluated and scored for lung parenchymal involvement. The impact of post-COVID lung injury and idiopathic pulmonary fibrosis on respiratory functions of were compared. The relationship of functional status and radiological involvement, as well as the effect of potential confounding factors were investigated. Results: A total of 71 patients were included in the study. Forty-eight (67.6%) of the patients were male and the mean age was 65.4 ± 10.3 years. Patients with post-COVID lung injury had greater 6-minute walk test distance and duration, as well as higher oxygen saturations. The MRC and Borg dyspnea scores were comparable. At radiologic evaluation, ground glass opacity scores were higher in patients with post-COVID lung injury, whereas pulmonary fibrosis scores were higher in patients with idiopathic pulmonary fibrosis. However, the total severity scores were similar. While pulmonary fibrosis score was found to have a negative correlation with 6-minute walk test distance, test duration, and pre- and post-test oxygen saturation levels, there was a positive correlation with oxygen saturation recovery time and MRC score. There was no relationship between ground glass opacity and the functional parameters. Conclusions: Despite having equal degrees of radiological involvement and dyspnea symptom severity, PCLI patients exhibited higher levels of functional status. This might be due to different pathophysiological mechanisms and radiological involvement patterns of both diseases. © 2023, The Author(s).
dc.identifier.DOI-ID10.1186/s12890-023-02527-z
dc.identifier.issn14712466
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11736
dc.language.isoEnglish
dc.publisherBioMed Central Ltd
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAged
dc.subjectCOVID-19
dc.subjectCross-Sectional Studies
dc.subjectDyspnea
dc.subjectFemale
dc.subjectFunctional Status
dc.subjectHumans
dc.subjectIdiopathic Pulmonary Fibrosis
dc.subjectLung Injury
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectBorg dyspnea scale
dc.subjectcontrolled study
dc.subjectcoronavirus disease 2019
dc.subjectcross-sectional study
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectdisease severity assessment
dc.subjectfemale
dc.subjectfibrosing alveolitis
dc.subjectfunctional assessment
dc.subjectfunctional status
dc.subjectground glass opacity
dc.subjecthuman
dc.subjectimage analysis
dc.subjectlung function
dc.subjectlung injury
dc.subjectlung parenchyma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectMedical Research Council Dyspnea Scale
dc.subjectmiddle aged
dc.subjectoxygen saturation
dc.subjectpathophysiology
dc.subjectradiological parameters
dc.subjectsix minute walk test
dc.subjecttreatment duration
dc.subjectcomplication
dc.subjectcoronavirus disease 2019
dc.subjectdiagnostic imaging
dc.subjectdyspnea
dc.subjectfibrosing alveolitis
dc.subjectfunctional status
dc.subjectlung injury
dc.titleRadiological findings based comparison of functional status in patients who have post-covid lung injury or idiopathic pulmonary fibrosis
dc.typeArticle

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