COVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkey

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dc.contributor.authorDuman M.
dc.contributor.authorŞık N.
dc.contributor.authorTekşam Ö.
dc.contributor.authorAkça H.
dc.contributor.authorKurt F.
dc.contributor.authorÇağlar A.A.
dc.contributor.authorYıldız L.A.
dc.contributor.authorTaşar M.A.
dc.contributor.authorFidancı İ.
dc.contributor.authorYayla B.C.C.
dc.contributor.authorYılmaz D.
dc.contributor.authorGüngör E.
dc.contributor.authorDemir Ş.
dc.contributor.authorÇokuğraş H.
dc.contributor.authorCebeci S.O.
dc.contributor.authorÖnal P.
dc.contributor.authorSaz E.U.
dc.contributor.authorYurtseven A.
dc.contributor.authorUysalol M.
dc.contributor.authorYıldız R.
dc.contributor.authorGümüş S.
dc.contributor.authorBal A.
dc.contributor.authorBayturan S.Ş.
dc.contributor.authorZengin N.
dc.contributor.authorAtik S.
dc.contributor.authorÇiftdoğan D.Y.
dc.contributor.authorBerksoy E.
dc.contributor.authorÇiçek A.
dc.contributor.authorŞahin S.
dc.contributor.authorKızıl M.C.
dc.contributor.authorKara Y.
dc.contributor.authorApa H.
dc.contributor.authorUlusoy E.
dc.contributor.authorKara A.A.
dc.contributor.authorYesil E.
dc.contributor.authorErdem M.
dc.contributor.authorTuran C.
dc.contributor.authorArslanoglu S.
dc.contributor.authorDuyu M.
dc.contributor.authorBesli G.E.
dc.contributor.authorArslan G.
dc.contributor.authorOflu A.T.
dc.contributor.authorÇeleğen M.
dc.contributor.authorBuldu E.
dc.contributor.authorPişkin İ.E.
dc.contributor.authorKardeş H.
dc.contributor.authorYılmaz H.L.
dc.contributor.authorYıldızdaş D.
dc.contributor.authorGökulu G.
dc.contributor.authorÇay P.
dc.contributor.authorÖzer U.
dc.contributor.authorGüleryüz O.D.
dc.contributor.authorÇolak Ö.
dc.contributor.authorGüneysu S.T.
dc.date.accessioned2024-07-22T08:03:56Z
dc.date.available2024-07-22T08:03:56Z
dc.date.issued2022
dc.description.abstractBackground: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical outcomes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population. Methods: This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, 2020, to May 31, 2021, children who were diagnosed with confirmed nasopharyngeal/tracheal specimen SARS-CoV-2 PCR positivity or positivity for serum-specific antibodies against SARS-CoV-2 were included. Demographics, presence of chronic illness, symptoms, history of contact with SARS-CoV-2 PCR-positive individuals, laboratory and radiologic investigations, clinical severity, hospital admissions, and prognosis were recorded. Results: A total of 8886 cases were included. While 8799 (99.0%) cases resulted in a diagnosis of SARS-CoV-2 with PCR positivity, 87 (1.0%) patients were diagnosed with MIS-C. Among SARS-CoV-2 PCR-positive patients, 51.0% were male and 8.5% had chronic illnesses. The median age was 11.6 years (IQR: 5.0–15.4) and 737 (8.4%) patients were aged <1 year. Of the patients, 15.5% were asymptomatic. The most common symptoms were fever (48.5%) and cough (30.7%) for all age groups. There was a decrease in the rate of fever as age increased (p < 0.001); the most common age group for this symptom was <1 year with the rate of 69.6%. There was known contact with a SARS-CoV-2 PCR-positive individual in 67.3% of the cases, with household contacts in 71.3% of those cases. In terms of clinical severity, 83 (0.9%) patients were in the severe-critical group. There was hospital admission in 1269 (14.4%) cases, with 106 (1.2%) of those patients being admitted to the pediatric intensive care unit (PICU). Among patients with MIS-C, 60.9% were male and the median age was 6.4 years (IQR: 3.9–10.4). Twelve (13.7%) patients presented with shock. There was hospital admission in 89.7% of these cases, with 29.9% of the patients with MIS-C being admitted to the PICU. Conclusion: Most SARS-CoV-2 PCR-positive patients presented with a mild clinical course. Although rare, MIS-C emerges as a serious consequence with frequent PICU admission. Further understanding of the characteristics of COVID-19 disease could provide insights and guide the development of therapeutic strategies for target groups. © 2022 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.ajem.2022.06.015
dc.identifier.issn07356757
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12494
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.rightsAll Open Access; Green Open Access
dc.subjectChild
dc.subjectCOVID-19
dc.subjectEmergency Service, Hospital
dc.subjectFemale
dc.subjectFever
dc.subjectHumans
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectSARS-CoV-2
dc.subjectSystemic Inflammatory Response Syndrome
dc.subjectantibiotic agent
dc.subjectfavipiravir
dc.subjecthydroxychloroquine
dc.subjecthypertensive factor
dc.subjectimmunoglobulin
dc.subjectimmunomodulating agent
dc.subjectlow molecular weight heparin
dc.subjectoseltamivir
dc.subjectSARS-CoV-2 antibody
dc.subjectsteroid
dc.subjectadolescent
dc.subjectage distribution
dc.subjectArticle
dc.subjectasymptomatic coronavirus disease 2019
dc.subjectchild
dc.subjectchronic disease
dc.subjectclinical examination
dc.subjectclinical feature
dc.subjectcomorbidity
dc.subjectcontact examination
dc.subjectcontrolled study
dc.subjectcoronavirus disease 2019
dc.subjectcoughing
dc.subjectdisease course
dc.subjectdisease severity
dc.subjectemergency ward
dc.subjectextracorporeal oxygenation
dc.subjectfemale
dc.subjectfever
dc.subjecthospital admission
dc.subjecthuman
dc.subjecthuman cell
dc.subjectinfant
dc.subjectlaboratory test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectmorbidity
dc.subjectnasopharyngeal swab
dc.subjectobservational study
dc.subjectpediatric intensive care unit
dc.subjectpediatric patient
dc.subjectpediatric ward
dc.subjectplasmapheresis
dc.subjectpolymerase chain reaction
dc.subjectpreschool child
dc.subjectprognosis
dc.subjectretrospective study
dc.subjectschool child
dc.subjectsex difference
dc.subjectshock
dc.subjectsystemic inflammatory response syndrome
dc.subjecttertiary care center
dc.subjectthorax radiography
dc.subjecttreatment planning
dc.subjectTurkey (republic)
dc.subjectclinical trial
dc.subjectcomplication
dc.subjectdiagnosis
dc.subjectepidemiology
dc.subjectfever
dc.subjecthospital emergency service
dc.subjectmulticenter study
dc.titleCOVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkey
dc.typeArticle

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