The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: A retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG)

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dc.contributor.authorTanriverdi O.
dc.contributor.authorMenekse S.
dc.contributor.authorTeker F.
dc.contributor.authorOktay E.
dc.contributor.authorPilanci K.N.
dc.contributor.authorGunaldi M.
dc.contributor.authorKocar M.
dc.contributor.authorKacan T.
dc.contributor.authorBahceci A.
dc.contributor.authorAvci N.
dc.contributor.authorAkman T.
dc.contributor.authorCokmert S.
dc.contributor.authorYesil-Cinkir H.
dc.contributor.authorYanmaz M.T.
dc.date.accessioned2024-07-22T08:11:53Z
dc.date.available2024-07-22T08:11:53Z
dc.date.issued2016
dc.description.abstractPurpose: To determine the predictive value of the mean platelet volume (MPV) and the MPV/platelet count ratio on the development of isolated bone metastasis in patients with breast cancer. Methods: A total of 121 previously untreatedfemale patients with isolated bone metastases from breast cancer (group 1) were included in this retrospective cohort study. The patients enrolled in this study had similar age, biological subtypes, and duration of follow-up after diagnosis. Group 1 was compared with both 71 previously untreated women with breast cancer with no metastases at all (group 2) and 39 healthy women (group 3). Demographic data, laboratory tests and histological features of all of the patients in groups 1 and 2 were recorded and the study variables from each of the three groups were compared. Results: In group 1, the cut-off value (9.2 fL) for the MPV was determined and patients were stratified into 4 subgroups. The MPV was higher in group 1 than in either group 2 or group 3. Group 1 patients had a MPV of 8.8±3.1 fL (mean 5.1, range: 6.1-15.6) and the cut-off value for MPV was 9.2 fl. For patients in group 1, the MPV distribution was stratified into 4 groups as follows: group A included MPV values <6.08 fL, in group B values ranged from 6.09 to 8.46 fL, group C included values from 8.47 to 10.05 fL, and group D included patients with MPV values >10.06fL MPV and the presence of lymphovascular invasion were found to be independent risk factors for the development of isolated bone metastases. Conclusion: We concluded that MPV can be used to predict the development of isolated bone metastases.
dc.identifier.issn11070625
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15825
dc.language.isoEnglish
dc.publisherZerbinis Publications
dc.subjectBone Neoplasms
dc.subjectBreast Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectMean Platelet Volume
dc.subjectMiddle Aged
dc.subjectPlatelet Count
dc.subjectResearch Personnel
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectTurkey
dc.subjectcalcium
dc.subjectlactate dehydrogenase
dc.subjectprogesterone receptor
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbone metastasis
dc.subjectbreast cancer
dc.subjectcontrolled study
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic test accuracy study
dc.subjectfemale
dc.subjecthuman
dc.subjectlymph vessel metastasis
dc.subjectmajor clinical study
dc.subjectpredictive value
dc.subjectreceiver operating characteristic
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectsensitivity and specificity
dc.subjectthrombocyte volume
dc.subjectbone tumor
dc.subjectbreast tumor
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectpersonnel
dc.subjectprocedures
dc.subjectthrombocyte count
dc.subjectthrombocyte volume
dc.subjectTurkey
dc.titleThe mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: A retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG)
dc.typeArticle

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