Ixekizumab for the treatment of the patients with moderate to severe plaque psoriasis: Clinical data from a real-world experience

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dc.contributor.authorGönülal M.
dc.contributor.authorAltunay İ.K.
dc.contributor.authorDoğan S.
dc.contributor.authorTürkmen M.
dc.contributor.authorBalcı D.D.
dc.contributor.authorÖztürkcan S.
dc.date.accessioned2024-07-22T08:03:41Z
dc.date.available2024-07-22T08:03:41Z
dc.date.issued2022
dc.description.abstractReal-life data about any particular treatment is very helpful for clinicians, particularly when managing a chronic disease such as psoriasis. In our study, we aimed to reflect our clinical experience during 48 weeks with an IL-17 antagonist ixekizumab. This study was designed as a retrospective multi-center study. Four tertiary referral centers participated into the study. The patients who did not present to the clinics for 3rd month follow-up were excluded. Data including gender, age, weight, type of psoriasis, additional sites on the body, disease duration, previous treatments, duration of medication of ixekizumab, psoriasis area and severity index scores, previous treatments, and comorbidities, the reasons for drug discontinuation, adverse effects and the patients' naïve or non-naïve status were retrieved from electronic patient folders. Although 267 patients met the inclusion criteria, 28 patients were excluded since they did not present to the clinic for 3rd month follow-up so 239 cases were included mmüne research. We determined significant correlations between naive and non-naive cases about getting PASI 75 and PASI 90 responses for all cases (p = 0.005 and p = 0.028, respectively) and between comorbid and non-comorbid cases about getting PASI 90 and PASI 100 responses for all cases (p = 0.021 and p = 0.029, respectively). When we investigate as female and male patients separately, non-comorbid female cases can achieve PASI 100 response significantly easier than comorbid female patients (p = 0.019). Clinicians can use ixekizumab safely mmüne treatment of their patients with psoriasis and get PASI 75-90-100 responses quickly. Ixekizumab is more effective for naive cases but it may also be a treatment option for biologic experienced patients. The ratio of PASI 75-90-100 responses are better in non-comorbid cases than comorbid patients nevertheless ixekizumab is a quite effective agent mmüne treatment of comorbid cases. © 2022 Wiley Periodicals LLC.
dc.identifier.DOI-ID10.1111/dth.15955
dc.identifier.issn13960296
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12382
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectAntibodies, Monoclonal, Humanized
dc.subjectDermatologic Agents
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPsoriasis
dc.subjectSeverity of Illness Index
dc.subjectTreatment Outcome
dc.subjectbiosimilar agent
dc.subjectixekizumab
dc.subjectdermatological agent
dc.subjectixekizumab
dc.subjectmonoclonal antibody
dc.subjectadult
dc.subjectadverse event
dc.subjectage distribution
dc.subjectArticle
dc.subjectbody weight
dc.subjectcohort analysis
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectCrohn disease
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectdrug withdrawal
dc.subjectelectronic health record
dc.subjectenteropathy
dc.subjecterythrodermic psoriasis
dc.subjectfemale
dc.subjectfollow up
dc.subjectguttate psoriasis
dc.subjecthuman
dc.subjectinjection site reaction
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical information
dc.subjectmiddle aged
dc.subjectnail psoriasis
dc.subjectpatient history of therapy
dc.subjectPsoriasis Area and Severity Index
dc.subjectpsoriasis vulgaris
dc.subjectpsoriatic arthritis
dc.subjectpustulosis palmoplantaris
dc.subjectretrospective study
dc.subjectscalp psoriasis
dc.subjectsex difference
dc.subjectthrush
dc.subjecttreatment duration
dc.subjecttreatment withdrawal
dc.subjectclinical trial
dc.subjectmulticenter study
dc.subjectpsoriasis
dc.subjectseverity of illness index
dc.subjecttreatment outcome
dc.titleIxekizumab for the treatment of the patients with moderate to severe plaque psoriasis: Clinical data from a real-world experience
dc.typeArticle

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