Cognitive functioning of adolescents using Methamphetamine: The impact of inflammatory and oxidative processes

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dc.contributor.authorÇakır B.
dc.contributor.authorUzun Çakır A.D.
dc.contributor.authorYalın Sapmaz Ş.
dc.contributor.authorBilaç Ö.
dc.contributor.authorTaneli F.
dc.contributor.authorKandemir H.
dc.date.accessioned2024-07-22T08:01:49Z
dc.date.available2024-07-22T08:01:49Z
dc.date.issued2024
dc.description.abstractBackground: Methamphetamine is a substance that causes neurotoxicity and its use is increasing in recent years. Literature highlights cognitive impairment resulting from Methamphetamine use. The aim of the present study is to evaluate the relationship between cognitive impairment and inflammatory processes in adolescents with Methamphetamine use disorder. Methods: The study included 69 adolescents aged 15–19 years, comprising 37 participants with Methamphetamine Use Disorder and 32 healthy controls. Central Nervous System Vital Signs was used to detect cognitive impairment. Childhood Trauma Questionnaire-33 and The Children’s Depression Inventory scales were used. In addition, venous blood was collected from the volunteers. Biochemical parameters (IL-1beta, IL-6, TNF-a, BDNF, FAM19A5, TAS, TOS) were analyzed. Results: Our study showed that (I) IL-6 and TNF-a levels of Methamphetamine users were lower than the healthy group; (II) BDNF levels of Methamphetamine users were higher than the healthy group; (III) mean Neurocognitive Index in cognitive tests of Methamphetamine using adolescents was negatively correlated with duration of Methamphetamine use and BDNF levels. Conclusions: Our study suggests that Methamphetamine use may have a negative effect on cognitive functions. © 2024 Taylor & Francis Group, LLC.
dc.identifier.DOI-ID10.1080/21622965.2024.2323643
dc.identifier.issn21622965
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11585
dc.language.isoEnglish
dc.publisherRoutledge
dc.titleCognitive functioning of adolescents using Methamphetamine: The impact of inflammatory and oxidative processes
dc.typeArticle

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