Aerobic exercise without multivitamin supplementation increased Serum homocysteine levels

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dc.contributor.authorDinç N.
dc.contributor.authorBereket-Yücel S.
dc.contributor.authorTaneli F.
dc.contributor.authorUlman C.
dc.contributor.authorTikiz H.
dc.date.accessioned2024-07-22T08:13:28Z
dc.date.available2024-07-22T08:13:28Z
dc.date.issued2015
dc.description.abstractAim: Aim of the study was to investigate the effects of aerobic exercise on cardiovascular risk factors such as Serum total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL), triglyceride (TG), lipoprotein (a) Lp(a), apolipoprotein A (Apo A), apolipoprotein B (Apo B), and homocysteine (Hcy) levels and to evaluate the impact of additional multivitamin supplementation on these parameters. Methods: Sixty volunteers (23.01±3.71 yrs, 173.20±9.88 cm, 6932±12.52 kg, 22.92±2.64 kg/m2) were enrolled in the study and randomized into the following 3 groups; multivitamin (MVG), placebo (PG) and control (CG). The volunteers in the MVG and PG attended 8 weeks of aerobic training program which was prescribed individually according to 60% of their maximum VO2. MVG were given a multivitamin supplement while PG were taken a placebo once daily for 8 weeks. Results: The analysis of the data indicated that the Hcy level of PG was significantly higher after 8 weeks of aerobic training, F(1 16) = 17.70, p=0.00. The increase in the MVG was not statistically significant after the multivitamin supplementation and aerobic training, p≥0.05. Unexpectedly, the simple effect analysis showed that there was a statistically significant decrease in HDL levels of both MVG and PG after eight weeks of aerobic training, F(1,17) = 7.67, p=0.01, F(1,16) = 16.00, p=0.02, respectively. Conclusion: Without multivitamin supplementation, aerobic exercise could lead to a significant increase in Hcy levels which has been considered an important cardiovascular risk factor. It is also possible that the baseline HDL levels of the participants could be another physiological variable that cause changes in the Hcy metabolism.
dc.identifier.issn03933660
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16347
dc.language.isoEnglish
dc.publisherEdizioni Minerva Medica
dc.subjectapolipoprotein A
dc.subjectapolipoprotein B
dc.subjecthigh density lipoprotein cholesterol
dc.subjecthomocysteine
dc.subjectlipoprotein A
dc.subjectlow density lipoprotein cholesterol
dc.subjectmultivitamin
dc.subjectplacebo
dc.subjecttriacylglycerol
dc.subjectaerobic exercise
dc.subjectArticle
dc.subjectcardiovascular risk
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectfemale
dc.subjecthuman
dc.subjectinvestigative procedures
dc.subjectlipoprotein blood level
dc.subjectmale
dc.subjectnormal human
dc.subjectrisk factor
dc.subjecttraining
dc.subjecttriacylglycerol blood level
dc.subjectvitamin supplementation
dc.titleAerobic exercise without multivitamin supplementation increased Serum homocysteine levels
dc.typeArticle

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