Effects of octreotide and morphine on the clearance rate of indium-111-pentetreotide from the epidural space

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dc.contributor.authorAydin Z.
dc.contributor.authorSayit E.
dc.contributor.authorErkin Y.
dc.contributor.authorÇapa G.
dc.contributor.authorErtay Y.
dc.contributor.authorSağiroğlu E.
dc.contributor.authorDurak H.
dc.date.accessioned2024-07-22T08:25:41Z
dc.date.available2024-07-22T08:25:41Z
dc.date.issued2000
dc.description.abstractIn this study we aimed to evaluate the possible mechanisms by which somatostatin acts when given epidurally. Twenty male New Zealand rabbits were randomly separated into four groups and various drugs were administered via a caudal epidural catheter. Group 1 received a bolus of 3.7 MBq indium-111 (In)-pentetreotide, group 2 received 200 μg octreotide and after 15 min a bolus of 3.7 MBq In-pentetreotide, group 3 received 0.1 mg morphine and after 15 min a bolus of 3.7 MBq In-pentetreotide, and group 4 received a bolus of 3.7 MBq technetium-99m (Tcm)-diethylene triamine pentaacetic acid (DTPA). Dynamic images of 60 min' duration were obtained from the posterior projection. T½ fast and T½ total clearance half-times were calculated. When unlabelled octreotide was given to block somatostatin receptors, clearance of In-pentetreotide was found to be faster. Epidural morphine administration did not change the clearance rate of In-pentetreotide. All these findings are in favour of octreotide binding to its probable own specific receptors present in the epidural space. © 2000 Lippincott Williams & Wilkins, Inc.
dc.identifier.DOI-ID10.1097/00006231-200009000-00009
dc.identifier.issn01433636
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20552
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectEpidural Space
dc.subjectIndium Radioisotopes
dc.subjectMale
dc.subjectMetabolic Clearance Rate
dc.subjectMorphine
dc.subjectOctreotide
dc.subjectRabbits
dc.subjectSomatostatin
dc.subjectdrug derivative
dc.subjectindium
dc.subjectmorphine
dc.subjectoctreotide
dc.subjectpentetreotide
dc.subjectsomatostatin
dc.subjectanimal
dc.subjectarticle
dc.subjectepidural space
dc.subjectmale
dc.subjectmetabolic clearance rate
dc.subjectmetabolism
dc.subjectrabbit
dc.titleEffects of octreotide and morphine on the clearance rate of indium-111-pentetreotide from the epidural space
dc.typeArticle

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