Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidative stress in various cancer cell lines
| dc.contributor.author | Firat, F | |
| dc.contributor.author | Özgül, M | |
| dc.contributor.author | Uluer, ET | |
| dc.contributor.author | Inan, S | |
| dc.date.accessioned | 2025-04-10T10:32:18Z | |
| dc.date.available | 2025-04-10T10:32:18Z | |
| dc.description.abstract | Cancer is a common cause of death worldwide. Approximately 80% of cancer patients use complementary or alternative medicines for treatment. Caffeic acid phenethyl ester (CAPE), the main active component of propolis, exhibits cytotoxic, antiproliferative and anti-cancer effects. Despite its anticancer effects CAPE exhibits no known harmful effects toward normal cells. We investigated the effects of CAPE on angiogenesis, apoptosis and oxidative stress using MDA MB-231, N2a and COLO 320 cell lines and CAPE treatments at 24 and 48 h. A two dimensional cell culture system was used and the findings were evaluated by an indirect immunohistochemical method and H-scores were calculated. CAPE was effective for all three cancer cell lines. After 24 and 48 h, we found a significant decrease in live cells and increased stress in the cells based on e-NOS and i-NOS levels. | |
| dc.identifier.e-issn | 1473-7760 | |
| dc.identifier.issn | 1052-0295 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/38718 | |
| dc.language.iso | English | |
| dc.title | Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidative stress in various cancer cell lines | |
| dc.type | Article |