The effects of botulinum-A toxin on bladder function and histology in spinal cord injured rats: Is there any difference between early and late application?

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dc.contributor.authorTemeltas G.
dc.contributor.authorTikiz C.
dc.contributor.authorDagci T.
dc.contributor.authorTuglu I.
dc.contributor.authorYavasoglu A.
dc.date.accessioned2024-07-22T08:24:04Z
dc.date.available2024-07-22T08:24:04Z
dc.date.issued2005
dc.description.abstractPurpose: We explored the effects of early and late application of botulinum-A toxin (BTX-A) on reservoir function and histological bladder changes in spinal cord injured rats. Materials and Methods: The study was done in 30 Sprague-Dawley rats randomly allocated into 5 groups. Group 1 of 6 rats underwent sham operation only. Group 2 of 6 rats underwent spinal cord transection. Group 3 of 6 rats underwent spinal cord transection followed by BTX-A application into the detrusor muscle 7 days later. Group 4 of 6 rats underwent spinal cord transection, followed by BTX-A application into the detrusor muscle 28 days later. Group 5 of 6 rats underwent spinal cord transection followed by saline injection into the detrusor muscle after 28 days. Spinal cord injury was created by transecting the cord at the T9 to T10 level. All rats underwent cystometric examination initially and on day 42 before sacrifice. The bladders were removed and examined histologically for fibrosis and hyperplasia. Results: On cystometric examination BTX-A caused an improvement in baseline pressure, and the frequency and amplitude of uninhibited detrusor contractions (p <0.001). No significant differences were observed in maximal bladder capacity or urethral opening pressure (p >0.05). Histologically BTX-A led to decreased fibrosis and hyperplasia (p <0.001). No significant differences were found between histological or cystometric among the groups with respect to receiving BTX-A in the early and late periods (p >0.05). Conclusions: BTX-A has a functional and histological healing effect on detrusor hyperreflexia subsequent to spinal cord injury in rats. Although administering BTX-A in the early period had better quantifiable functional and histological outcomes compared to the late period, the difference was not statistically significant. Copyright © 2005 by American Urological Association.
dc.identifier.DOI-ID10.1097/01.ju.0000180410.78774.b5
dc.identifier.issn00225347
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19812
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectbotulinum toxin A
dc.subjectadolescent
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbladder capacity
dc.subjectbladder function
dc.subjectbladder pressure
dc.subjectchronopharmacology
dc.subjectcontrolled study
dc.subjectdetrusor hyperreflexia
dc.subjectdetrusor muscle
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfibrosis
dc.subjecthistopathology
dc.subjecthyperplasia
dc.subjecthyperreflexia
dc.subjectnonhuman
dc.subjectoveractive bladder
dc.subjectpriority journal
dc.subjectrat
dc.subjectspinal cord injury
dc.subjectspinal cord transsection
dc.subjecturethra pressure
dc.subjecturodynamics
dc.titleThe effects of botulinum-A toxin on bladder function and histology in spinal cord injured rats: Is there any difference between early and late application?
dc.typeArticle

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