Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism
No Thumbnail Available
Date
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
This study was designed to show the effect of propylthiouracil treatment on sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels on subjects with subclinical hyperthyroidism. After checking sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels of 35 patients with subclinical hyperthyroidism, each was given 50 mg tablets of propylthiouracil three times daily. After 3 months, sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels were then compared to the levels before treatment. Although high-sensitivity C-reactive protein and sCD40L levels were normal in the subclinical hyperthyroidism patients compared to the healthy controls, fetuin-A levels were statistically significantly higher (*p = 0.022). After treatment, fetuin-A levels of subclinical hyperthyroidism patients decreased statistically significantly compared to the levels before treatment (**p = 0.026). sCD40L and high-sensitivity C-reactive protein levels did not have a statistically significant difference compared to the control group and post-propylthiouracil treatment. In subclinical hyperthyroidism patients, high fetuin-A levels before propylthiouracil treatment and decreases in these levels after treatment in cases with subclinical hyperthyroidism indicated the possibility of preventing long-term cardiac complications with propylthiouracil treatment. © 2013 Springer Science+Business Media New York.
Description
Keywords
Adult , alpha-2-HS-Glycoprotein , Antithyroid Agents , Biological Markers , C-Reactive Protein , Case-Control Studies , CD40 Ligand , Dose-Response Relationship, Drug , Female , Humans , Hyperthyroidism , Male , Propylthiouracil , Retrospective Studies , Treatment Outcome , C reactive protein , CD40 ligand , fetuin A , liothyronine , propylthiouracil , thyrotropin , thyroxine , adult , article , chemiluminescence analyzer , chemiluminescence immunoassay , clinical article , controlled study , ELISA kit , enzyme linked immunosorbent assay , female , human , liothyronine blood level , male , priority journal , protein blood level , subclinical hyperthyroidism , subclinical hypothyroidism , thyrotropin blood level , thyroxine blood level , treatment duration , treatment outcome