Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

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dc.contributor.authorErdurak K.
dc.contributor.authorDundar P.E.
dc.contributor.authorOzyurt B.C.
dc.contributor.authorNegri E.
dc.contributor.authorLa Vecchia C.
dc.contributor.authorTay Z.
dc.date.accessioned2024-07-22T08:17:57Z
dc.date.available2024-07-22T08:17:57Z
dc.date.issued2014
dc.description.abstractThe aim of the study was to identify and quantify the reasons for the high bladder cancer rates in Turkey. We conducted a case-control study in Manisa, Turkey, in 2011. The study included 173 patients with incident, histologically confirmed bladder cancer and 282 controls who were frequency matched by age, sex and geographic area, admitted to the main hospital of Manisa for a wide range of acute diseases. Adjusted odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were derived from multiple logistic regression models. Compared with never smokers, the OR was 2.9 (95% CI 1.5-5.4) for moderate (<20 cigarettes/day) and 4.0 (95% CI 1.7-9.6) for heavy smokers. The association was stronger for unfiltered black tobacco (OR=5.4) and for longer duration of smoking (≥40 years, OR=5.3). There was a strong inverse correlation with social class indicators, with ORs of 0.2 (95% CI 0.1-0.4) for more-educated compared with less-educated individuals. There was no significant association with a group of five occupations a priori defined as being of high risk (OR=1.3), nor with farming (OR=1.2). Bladder cancer risk was directly related to the history of urinary tract infections (OR=1.9, 95% CI 1.2-3.1) but not to diabetes (OR=0.7) or kidney (OR=0.7) and prostate (OR=1.3) diseases. Tobacco is the major risk factor for bladder cancer in Manisa, being responsible for 56% of cases; urinary tract infections account for 19% of cases, whereas the role of occupational exposure is limited in this, predominantly rural, population. © 2013 Wolters Kluwer Health.
dc.identifier.DOI-ID10.1097/CEJ.0b013e3283631dde
dc.identifier.issn14735709
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17165
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCase-Control Studies
dc.subjectDiabetes Complications
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectKidney Diseases
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOccupational Exposure
dc.subjectOccupations
dc.subjectPrognosis
dc.subjectProstatic Diseases
dc.subjectSmoking
dc.subjectTurkey
dc.subjectUrinary Bladder Neoplasms
dc.subjectUrinary Tract Infections
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbladder cancer
dc.subjectcancer risk
dc.subjectcase control study
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectnephrolithiasis
dc.subjectoccupation
dc.subjectoccupational exposure
dc.subjectpriority journal
dc.subjectprostate disease
dc.subjectsmoking
dc.subjectsocial class
dc.subjecttobacco
dc.subjectTurkey (republic)
dc.subjecturinary tract infection
dc.titleSmoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey
dc.typeArticle

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