The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages

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dc.contributor.authorTaneli F.
dc.contributor.authorErsoy B.
dc.contributor.authorÖzhan B.
dc.contributor.authorÇalkan M.
dc.contributor.authorYilmaz Ö.
dc.contributor.authorDinç G.
dc.contributor.authorGenç A.
dc.contributor.authorTaneli C.
dc.date.accessioned2024-07-22T08:20:46Z
dc.date.available2024-07-22T08:20:46Z
dc.date.issued2010
dc.description.abstractObjectives: The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. Design and methods: Eighty adolescent boys were grouped (n=20) as; Group1: obese-Tanner2, Group2: non-obese-Tanner2, Group3: obese-Tanner4, Group4: non-obese-Tanner4. Serum INSL3, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, estradiol, sex hormone binding globulin, inhibin B and leptin levels were assessed in all groups. Results: INSL3 levels were significantly lower in obese adolescents compared to non-obese boys (p=0.003, Tanner2) and (p=0.031, Tanner4). There was a negative correlation between INSL3 and leptin (r=-0.468, p=0.001). The negative correlation between INSL3 and BMISDS indicates that pubertal obesity leads to Leydig cell impairment. Conclusions: This study demonstrated for the first time in the literature that obesity effects testicular Leydig cell function starting from Tanner stage 2. © 2010.
dc.identifier.DOI-ID10.1016/j.clinbiochem.2010.07.026
dc.identifier.issn00099120
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18315
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectHumans
dc.subjectInhibins
dc.subjectInsulin
dc.subjectLeptin
dc.subjectLuteinizing Hormone
dc.subjectMale
dc.subjectObesity
dc.subjectProteins
dc.subjectPuberty
dc.subjectTestis
dc.subjectTestosterone
dc.subjectestradiol
dc.subjectfollitropin
dc.subjectinhibin B
dc.subjectinsulin like factor 3
dc.subjectleptin
dc.subjectluteinizing hormone
dc.subjectsex hormone binding globulin
dc.subjecttestis peptide hormone
dc.subjecttestosterone
dc.subjectunclassified drug
dc.subjectadolescent
dc.subjectarticle
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfollitropin blood level
dc.subjecthormone blood level
dc.subjecthuman
dc.subjectLeydig cell
dc.subjectluteinizing hormone blood level
dc.subjectmale
dc.subjectobesity
dc.subjectpriority journal
dc.subjectpuberty
dc.subjectschool child
dc.subjecttestis function
dc.subjecttestis size
dc.titleThe effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages
dc.typeArticle

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