Staged-surgery with permanent pathology for the management of high-risk nonmelanoma skin cancer of the nose
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Date
2011
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Abstract
The objective of the study was to investigate the effect of staged-surgery with permanent pathology on tumour recurrence of high-risk nonmelanoma skin cancers (NMSCs) of the nose and to determine the factors associated with subclinical spread and deep-margin involvement. Twenty-one patients who underwent staged-surgery with permanent pathology for high-risk NMSCs of the nose between 2007 and 2008 were prospectively followed-up for tumour recurrence. The incidence of tumour recurrence after staged-surgery with permanent pathology was 0%. A positive correlation between perineural involvement and subclinical spread (p = .012); and a statistically significant relationship between infiltrative type basal cell carcinoma (BCC) and deep-margin involvement (p = .033) was detected. Staged-surgery with permanent pathology is a reliable surgical method for complete excision of high-risk NMSCs of the nose and provides a significant decrease in tumour recurrence. Perineural involvement may cause subclinical spread, and infiltrative type BCC may invade deeper structures of the nose. © 2010 Springer-Verlag.
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Keywords
Adult , Aged , Aged, 80 and over , Carcinoma, Basal Cell , Carcinoma, Squamous Cell , Chi-Square Distribution , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Nose Neoplasms , Prospective Studies , Reconstructive Surgical Procedures , Risk Factors , Statistics, Nonparametric , Surgical Flaps , Treatment Outcome , adult , aged , article , cancer surgery , clinical article , female , follow up , human , male , metastasis , nonmelanoma skin cancer , nose cancer , priority journal , skin cancer , tumor recurrence