Morphological changes and vascular reactivity of rat thoracic aorta twelve months after; [Pinealectomy pinealektomiden on İki ay sonra sıçanların torasik aortalarındaki morfolojik deǧişiklikler ve vasküler reaktivite]

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dc.contributor.authorKurçer Z.
dc.contributor.authorÖztürk F.
dc.contributor.authorŞahna E.
dc.contributor.authorKuruş M.
dc.contributor.authorÖlmez E.
dc.date.accessioned2024-07-22T08:21:11Z
dc.date.available2024-07-22T08:21:11Z
dc.date.issued2010
dc.description.abstractObjective: Melatonin, a hormone produced by the pineal gland, has been suggested to protect against development of hypertension and atherosclerosis. In this study, the effects of long-term melatonin deficiency for twelve months after pinealectomy on the α-adrenergic-contractions induced by phenylephrine, endothelium-dependent relaxation responses to acetylcholine and the morphological changes in the rat thoracic aorta were studied. Material and Metods: Rats were pinealectomized twelve months before the beginning of the vasomotor studies. Rings of arteries were mounted in isolated tissue baths for the measurements of isometric contractile force. The contractile responses to phenylephrine and endothelium-dependent relaxation responses to acetylcholine in the vessels were evaluated. Endothelial function was evaluated by vascular relaxation to acetylcholine. Histological examinations demonstrated the alterations of tunica media in the vessels of pinealectomized rats. Results: Thick and thin areas were observed in the transverse sections of vessels and the ratio of the widest media thickness to the narrowest was found significantly increased in pinealectomized group (2.85 ± 0.56) when compared to the control group (1.65 ± 0.10). In addition, α-smooth muscle actin and elastic lamellae staining of the media were attenuated in pinealectomized rats. Al-though contractile responses of vessels to phenylephrine in pinealectomized rats were lower than control group, significant difference was found for only one concentration (3x 10-8 mol l-1) of phenylephrine. There was no difference between the relaxation responses to acetylcholine in pinealectomized and control groups. Conclusion: These results show that long-term melatonin deficiency may cause some morphological changes in the tunica media of vessels. However, the function of endothelium and vascular responsiveness to α-adrenergic stimulus seem to be mostly protected. © 2010 by Türkiye Klinikleri.
dc.identifier.DOI-ID10.5336/medsci.2008-9296
dc.identifier.issn13000292
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18494
dc.language.isoTurkish
dc.publisherTurkiye Klinikleri
dc.rightsAll Open Access; Green Open Access; Hybrid Gold Open Access
dc.subjectacetylcholine
dc.subjectalpha smooth muscle actin
dc.subjectmelatonin
dc.subjectphenylephrine
dc.subjectadventitia
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarterial wall thickness
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectblood vessel reactivity
dc.subjectcontrolled study
dc.subjectendothelium
dc.subjecthistology
dc.subjecthormone blood level
dc.subjecthormone deficiency
dc.subjectmale
dc.subjectnonhuman
dc.subjectpinealectomy
dc.subjectrat
dc.subjectthoracic aorta
dc.subjecttunica media
dc.titleMorphological changes and vascular reactivity of rat thoracic aorta twelve months after; [Pinealectomy pinealektomiden on İki ay sonra sıçanların torasik aortalarındaki morfolojik deǧişiklikler ve vasküler reaktivite]
dc.typeArticle

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