Response of mouse bone marrow mesenchymal stem cells to graphene-containing grid-like bioactive glass scaffolds produced by robocasting

Simple item page
dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorTürk M.
dc.contributor.authorAtmaca H.
dc.date.accessioned2024-07-22T08:09:29Z
dc.date.available2024-07-22T08:09:29Z
dc.date.issued2018
dc.description.abstractIn the study, three-dimensional, grid-like silicate-based bioactive glass scaffolds were manufactured using a robotic deposition technique. Inks were prepared by mixing 13-93 bioactive glass particles in Pluronic® F-127 solution. After deposition, scaffolds were dried at room temperature and sintered at 690°C for 1 h. The surface of the sintered scaffolds was coated with graphene nanopowder (1, 3, 5, 10 wt%) containing poly(ε-caprolactone) solution. The in vitro mineralization ability of the prepared composite scaffolds was investigated in simulated body fluid. The surface of the simulated body fluid-treated scaffolds was analyzed using scanning electron microscopy to investigate the hydroxyapatite formation. Mechanical properties were tested under compression. Results revealed that graphene coating has no detrimental effect on the hydroxyapatite forming ability of the prepared glass scaffolds. On the other hand, it decreased the compression strength of the scaffolds at high graphene concentrations. The prepared grid-like bioactive glass-based composite scaffolds did not show toxic response to bone marrow mesenchymal stem cells. It was shown that stem cells seeded onto the scaffolds attached and proliferated well on the surface. Cells seeded on the scaffolds surface also demonstrated osteogenic differentiation under in vitro conditions in the absence of transforming growth factors. © The Author(s) 2018.
dc.identifier.DOI-ID10.1177/0885328218799610
dc.identifier.issn08853282
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14845
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectCell Adhesion
dc.subjectCell Proliferation
dc.subjectCompressive Strength
dc.subjectDurapatite
dc.subjectGlass
dc.subjectGraphite
dc.subjectMesenchymal Stem Cells
dc.subjectMice
dc.subjectNanoparticles
dc.subjectOsteogenesis
dc.subjectPoloxamer
dc.subjectPolyesters
dc.subjectSilicates
dc.subjectTissue Scaffolds
dc.subjectBioactive glass
dc.subjectBiomechanics
dc.subjectBody fluids
dc.subjectBone
dc.subjectCell culture
dc.subjectDeposition
dc.subjectGraphene
dc.subjectHydroxyapatite
dc.subjectScaffolds
dc.subjectScanning electron microscopy
dc.subjectSilicates
dc.subjectSintering
dc.subjectStem cells
dc.subjectgraphene
dc.subjecthydroxyapatite
dc.subjectpolycaprolactone
dc.subject13-93 bioactive glass
dc.subjectbiomaterial
dc.subjectglass
dc.subjectgraphite
dc.subjectnanoparticle
dc.subjectpoloxamer
dc.subjectpolyester
dc.subjectsilicate
dc.subjectBone marrow mesenchymal stem cells
dc.subjectGlass-based composites
dc.subjectHydroxyapatite formations
dc.subjectMesenchymal stem cell
dc.subjectOsteogenic differentiation
dc.subjectPoly (epsiloncaprolactone)
dc.subjectRobocasting
dc.subjectTransforming growth factors
dc.subjectanimal cell
dc.subjectArticle
dc.subjectbone marrow derived mesenchymal stem cell
dc.subjectcell adhesion
dc.subjectcell differentiation
dc.subjectcell proliferation
dc.subjectcell structure
dc.subjectcell viability
dc.subjectchemical structure
dc.subjectcompression
dc.subjectcompressive strength
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectgrid like bioactive glass scaffold
dc.subjectin vitro study
dc.subjectmaterial coating
dc.subjectmineralization
dc.subjectmouse
dc.subjectnonhuman
dc.subjectporosity
dc.subjectpriority journal
dc.subjectrobocasting
dc.subjectrobotics
dc.subjectscanning electron microscopy
dc.subjectsimulation
dc.subjectanimal
dc.subjectbone development
dc.subjectchemistry
dc.subjectcytology
dc.subjectmesenchymal stem cell
dc.subjecttissue scaffold
dc.subjectScaffolds (biology)
dc.titleResponse of mouse bone marrow mesenchymal stem cells to graphene-containing grid-like bioactive glass scaffolds produced by robocasting
dc.typeArticle

Files

Collections

Scopus Koleksiyonu