Evaluation of the relation between interstitial cells of cajal (CD117) and serotonin receptor (5HT-3A) with postfundoplication dysphagia

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dc.contributor.authorOzcan C.U.
dc.contributor.authorYilmaz O.
dc.contributor.authorGurer D.E.
dc.contributor.authorAyhan S.
dc.contributor.authorTaneli C.
dc.contributor.authorGenc A.
dc.date.accessioned2024-07-22T08:14:37Z
dc.date.available2024-07-22T08:14:37Z
dc.date.issued2015
dc.description.abstractObjective: The aim of the present study is to investigate the effect of Nissen fundoplication to the pacemaker cells of an intestinal system and the serotonin receptors on an ICC membrane. Methods: Sixteen adult male rats were taken into study. Rats were divided in to the following two groups. Nissen fundoplication was performed to study group (Group 1) and no surgical procedures were applied to control group (group 2). The rats who were subjected to surgery and the rats without surgery were sacrificed on to postoperative 14 days. Specimens for the pathologic analysis were obtained from upper esophagus (group A) and esophagogastric junction (EGJ) (group B). Distribution of ICC and 5HT-3A were evaluated separately. Results: There was a significant difference (p=0.01, p=0.02, respectively) regarding number of cells stained with CD117 between the group 1B-2B and group 2A-2B. Also there was a significant difference between (p=0.01, p=0.01 respectively) number of cells stained with 5HT-3A in groups 1A-1B and 2A-2B. However, no correlation was detected between group 1B-2B for 5HT-3A. Conclusion: A reduction in the number of ICC was observed in esophagogastric junctions of the fundoplication group but 5HT-3A distribution did not show a significant difference. A decrease in the number of ICC may be effective at postfundoplication dysphagia. © 2014 Surgical Associates Ltd.
dc.identifier.DOI-ID10.1016/j.ijsu.2014.11.053
dc.identifier.issn17439191
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16628
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectDeglutition Disorders
dc.subjectEsophagogastric Junction
dc.subjectFundoplication
dc.subjectInterstitial Cells of Cajal
dc.subjectMale
dc.subjectProto-Oncogene Proteins c-kit
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Serotonin, 5-HT3
dc.subjectserotonin 3A receptor
dc.subjectstem cell factor receptor
dc.subjectserotonin 3 receptor
dc.subjectstem cell factor receptor
dc.subjectadult
dc.subjectanimal experiment
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectdysphagia
dc.subjectesophagus
dc.subjecthistopathology
dc.subjectinterstitial cell of Cajal
dc.subjectlower esophagus sphincter
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstomach fundoplication
dc.subjectswallowing
dc.subjectadverse effects
dc.subjectanimal
dc.subjectDeglutition Disorders
dc.subjectinterstitial cell of Cajal
dc.subjectmetabolism
dc.subjectpathology
dc.subjectphysiology
dc.subjectstomach fundoplication
dc.subjectWistar rat
dc.titleEvaluation of the relation between interstitial cells of cajal (CD117) and serotonin receptor (5HT-3A) with postfundoplication dysphagia
dc.typeArticle

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