Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Cystoid Macular Edema

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dc.contributor.authorMansour A.M.
dc.contributor.authorSheheitli H.
dc.contributor.authorKucukerdonmez C.
dc.contributor.authorSisk R.A.
dc.contributor.authorMoura R.
dc.contributor.authorMoschos M.M.
dc.contributor.authorLima L.H.
dc.contributor.authorAl-Shaar L.
dc.contributor.authorArevalo J.F.
dc.contributor.authorMaia M.
dc.contributor.authorFoster R.E.
dc.contributor.authorKayikcioglu O.
dc.contributor.authorKozak I.
dc.contributor.authorKurup S.
dc.contributor.authorZegarra H.
dc.contributor.authorGallego-Pinazo R.
dc.contributor.authorHamam R.N.
dc.contributor.authorBejjani R.A.
dc.contributor.authorCinar E.
dc.contributor.authorErakgün E.T.
dc.contributor.authorKimura A.
dc.contributor.authorTeixeira A.
dc.date.accessioned2024-07-22T08:09:58Z
dc.date.available2024-07-22T08:09:58Z
dc.date.issued2018
dc.description.abstractPurpose: To report the clinical outcome after intravitreal dexamethasone implant in patients with retinitis pigmentosa and cystoid macular edema. Methods: Multicenter retrospective case series of eyes with retinitis pigmentosa and cystoid macular edema that underwent intravitreal dexamethasone implant. Primary outcome measures were best-corrected visual acuity in LogMAR and central macular thickness. Statistical analyses used two-tailed comparison with Wilcoxon signed-rank test. Results: There were a total of 45 eyes from 34 patients with a mean age of 32.7 years (range 16-57) and mean follow-up of 15.5 ± 13.0 months. At Month 3 after the first injection, mean initial best-corrected visual acuity improved from 0.61 ± 0.38 (20/81) to 0.37 ± 0.16 (20/47) (P = 0.012), whereas mean central macular thickness (m) decreased from 506 ± 288 m to 311.7 ± 71.6 m (P < 0.001) and mean intraocular pressure increased from 15.7 ± 2.3 mmHg to 19.8 ± 11.0 mmHg (P = 0.01). Fourteen eyes had multiple injections (1-7 reinjections) at a mean interval of 6 months. Treatment effect was durable with multiple injections, but with seven eyes developing visually significant cataracts. Conclusion: Best-corrected visual acuity improved up to 4 months in around half of the eyes. Eyes that benefited the most were pseudophakic, steroid nonresponsive, with large initial central macular thickness, and profuse fluorescein dye leakage. © Ophthalmic Communications Society, Inc.
dc.identifier.DOI-ID10.1097/IAE.0000000000001542
dc.identifier.issn0275004X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15026
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectAdolescent
dc.subjectAdult
dc.subjectDexamethasone
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Implants
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGlucocorticoids
dc.subjectHumans
dc.subjectIntravitreal Injections
dc.subjectMacula Lutea
dc.subjectMacular Edema
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetinitis Pigmentosa
dc.subjectRetrospective Studies
dc.subjectTime Factors
dc.subjectTomography, Optical Coherence
dc.subjectTreatment Outcome
dc.subjectVisual Acuity
dc.subjectYoung Adult
dc.subjectdexamethasone
dc.subjectfluorescent dye
dc.subjectdexamethasone
dc.subjectglucocorticoid
dc.subjectadult
dc.subjectArticle
dc.subjectbest corrected visual acuity
dc.subjectcataract
dc.subjectcentral macular thickness
dc.subjectclinical article
dc.subjectdrug efficacy
dc.subjectdrug treatment failure
dc.subjectfemale
dc.subjecthuman
dc.subjectintraocular pressure
dc.subjectmale
dc.subjectoutcome assessment
dc.subjectpseudophakia
dc.subjectretina macula cystoid edema
dc.subjectretinitis pigmentosa
dc.subjectretrospective study
dc.subjectsteroid therapy
dc.subjecttherapy resistance
dc.subjectadolescent
dc.subjectclinical trial
dc.subjectcomplication
dc.subjectdose response
dc.subjectdrug effect
dc.subjectdrug implant
dc.subjectfollow up
dc.subjectintravitreal drug administration
dc.subjectmacular edema
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectoptical coherence tomography
dc.subjectpathology
dc.subjectretina macula lutea
dc.subjectretinitis pigmentosa
dc.subjecttime factor
dc.subjecttreatment outcome
dc.subjectvisual acuity
dc.subjectyoung adult
dc.titleIntravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Cystoid Macular Edema
dc.typeArticle

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