The effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women

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dc.contributor.authorBuyukyazi G.
dc.contributor.authorUlman C.
dc.contributor.authorÇelik A.
dc.contributor.authorÇetinkaya C.
dc.contributor.authorSisman A.R.
dc.contributor.authorÇimrin D.
dc.contributor.authorDogru Y.
dc.contributor.authorKaya D.
dc.date.accessioned2024-07-22T08:10:54Z
dc.date.available2024-07-22T08:10:54Z
dc.date.issued2017
dc.description.abstractObjective: Hepcidin may be an important mediator in exercise-induced iron deficiency. Despite the studies investigating acute exercise effects on hepcidin and markers of iron metabolism, we found no studies examining the chronic effects of walking exercises (WE) on hepcidin and markers of iron metabolism in premenopausal women. The chronic effects of two 8-week different-intensity WE on hepcidin, interleukin 6 (IL-6), and markers of iron metabolism in pre-menopausal women were examined. Methods: Exercise groups (EG) [moderate tempo walking group (MTWG), n = 11; brisk walking group (BWG), n = 11] walked 3 days/week, starting from 30 to 51 min. Control group (CG; n = 8) did not perform any exercises. BWG walked at ∼70%-75%; MTWG at ∼50%-55% of HRRmax. VO2max, hepcidin, IL-6, and iron metabolism markers were determined before and after the intervention. Results: VO2max increased in both EGs, favoring the BWG. Hepcidin increased in the BWG (p < 0.01) and CG (p < 0.05). IL-6 decreased in the BWG and the MTWG (p < 0.05; p < 0.01). While iron, ferritin, transferrin, and transferrin saturation levels did not change in any group, total iron binding capacity (p < 0.05), red blood cells (p < 0.05), and hematocrit (p < 0.01) increased only in the BWG. Conclusion: Both WE types may be useful to prevent inflammation. However, brisk walking is advisable due to the positive changes in VO2max and some iron metabolism parameters, which may contribute to prevent iron deficiency. The increase in hepcidin levels remains unclear and necessitates further studies. © 2017 Akadémiai Kiadó, Budapest.
dc.identifier.DOI-ID10.1556/2060.104.2017.1.7
dc.identifier.issn2498602X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15438
dc.language.isoEnglish
dc.publisherAkademiai Kiado ZRt.
dc.rightsAll Open Access; Green Open Access
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectExercise
dc.subjectFemale
dc.subjectHepcidins
dc.subjectHumans
dc.subjectInflammation Mediators
dc.subjectInterleukin-6
dc.subjectIron
dc.subjectMiddle Aged
dc.subjectOxygen Consumption
dc.subjectPremenopause
dc.subjectTime Factors
dc.subjectWalking
dc.subjectbiological marker
dc.subjecthepcidin
dc.subjectinterleukin 6
dc.subjectiron
dc.subjectautacoid
dc.subjectHAMP protein, human
dc.subjecthepcidin
dc.subjectIL6 protein, human
dc.subjectinterleukin 6
dc.subjectiron
dc.subjectadult
dc.subjectArticle
dc.subjectblood analysis
dc.subjectcontrolled study
dc.subjectenzyme linked immunosorbent assay
dc.subjecterythrocyte
dc.subjectexercise
dc.subjectfemale
dc.subjecthematocrit
dc.subjecthuman
dc.subjectiron binding capacity
dc.subjectiron blood level
dc.subjectiron metabolism
dc.subjectpremenopause
dc.subjectwalking
dc.subjectblood
dc.subjectcomparative study
dc.subjectexercise
dc.subjectmiddle aged
dc.subjectoxygen consumption
dc.subjectphysiology
dc.subjectpremenopause
dc.subjectrandomized controlled trial
dc.subjecttime factor
dc.titleThe effect of 8-week different-intensity walking exercises on serum hepcidin, IL-6, and iron metabolism in pre-menopausal women
dc.typeArticle

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