Effects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: A randomized, double-blind, parallel trial

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dc.contributor.authorÖztürk T.
dc.contributor.authorAğdanlı D.
dc.contributor.authorBayturan Ö.
dc.contributor.authorÇıkrıkcı C.
dc.contributor.authorKeleş G.T.
dc.date.accessioned2024-07-22T08:14:15Z
dc.date.available2024-07-22T08:14:15Z
dc.date.issued2015
dc.description.abstractMyocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval (QTc) prolongation. The objective of this randomized, double-blind trial was to determine the effects of high- vs conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias following anesthesia induction and intubation. Fifty patients about to undergo coronary artery surgery were randomly allocated to receive conventional-dose (0.6 mg/kg, group C, n=25) or high-dose (1.2 mg/kg, group H, n=25) rocuronium after induction with etomidate and fentanyl. QTc, heart rate, and mean arterial pressure were recorded before induction (T0), after induction (T1), after rocuronium (just before laryngoscopy; T2), 2 min after intubation (T3), and 5 min after intubation (T4). The occurrence of dysrhythmias was recorded. In both groups, QTc was significantly longer at T3 than at baseline [475 vs 429 ms in group C (P=0.001), and 459 vs 434 ms in group H (P=0.005)]. The incidence of dysrhythmias in group C (28%) and in group H (24%) was similar. The QTc after high-dose rocuronium was not significantly longer than after conventional-dose rocuronium in patients about to undergo coronary artery surgery who were induced with etomidate and fentanyl. In both groups, compared with baseline, QTc was most prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to the nociceptive stimulus of intubation. © 2015, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.
dc.identifier.DOI-ID10.1590/1414-431X20144294
dc.identifier.issn1414431X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16526
dc.language.isoEnglish
dc.publisherAssociacao Brasileira de Divulgacao Cientifica
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAged
dc.subjectAndrostanols
dc.subjectAnesthesia, General
dc.subjectAnesthetics, Intravenous
dc.subjectArrhythmias, Cardiac
dc.subjectArterial Pressure
dc.subjectCoronary Vessels
dc.subjectDouble-Blind Method
dc.subjectElectrocardiography
dc.subjectEtomidate
dc.subjectFemale
dc.subjectFentanyl
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectIntubation
dc.subjectLaryngoscopy
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuromuscular Nondepolarizing Agents
dc.subjectStatistics, Nonparametric
dc.subjectetomidate
dc.subjectfentanyl
dc.subjectrocuronium
dc.subjectandrostane derivative
dc.subjectetomidate
dc.subjectfentanyl
dc.subjectintravenous anesthetic agent
dc.subjectneuromuscular blocking agent
dc.subjectrocuronium
dc.subjectadult
dc.subjectanesthesia induction
dc.subjectArticle
dc.subjectclinical assessment
dc.subjectclinical trial
dc.subjectcontrolled study
dc.subjectcoronary artery surgery
dc.subjectdouble blind procedure
dc.subjectdrug megadose
dc.subjectelectrocardiography
dc.subjectfemale
dc.subjectheart arrhythmia
dc.subjectheart muscle ischemia
dc.subjectheart rate
dc.subjecthuman
dc.subjectintubation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectmiddle aged
dc.subjectoutcome assessment
dc.subjectpatient monitoring
dc.subjectQT prolongation
dc.subjectrandomized controlled trial
dc.subjectadverse effects
dc.subjectaged
dc.subjectArrhythmias, Cardiac
dc.subjectarterial pressure
dc.subjectcoronary blood vessel
dc.subjectdrug effects
dc.subjectgeneral anesthesia
dc.subjectintubation
dc.subjectlaryngoscopy
dc.subjectnonparametric test
dc.subjectprocedures
dc.subjectsurgery
dc.titleEffects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: A randomized, double-blind, parallel trial
dc.typeArticle

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