Profiling of apoptosis-associated proteins in human prostate cancer cells in response to Montivipera bulgardaghica albizona venom by protein array

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dc.contributor.authorIlhan S.
dc.contributor.authorÇiçek K.
dc.contributor.authorTok C.V.
dc.contributor.authorAtmaca H.
dc.date.accessioned2024-07-22T08:06:51Z
dc.date.available2024-07-22T08:06:51Z
dc.date.issued2021
dc.description.abstractHere we studied the possible cytotoxic and apoptotic effects of Anatolian endemic mountain viper, Montivipera bulgardaghica albizona (M.b. albizona) venom on human PC-3 and DU-145 prostate cancer cell lines. M.b. albizona venom induced cytotoxicity and apoptosis of both prostate cancer cells in a concentration-dependent manner. Protein array results revealed that the levels of major components of the mitochondrion-initiated and the extrinsic death receptor-mediated pathways were significantly changed in prostate cancer cells by venom treatment. These data suggest that one or more of the purified components of the M.b. albizona venom may serve as an appropriate therapeutic agent for prostate cancer. Further bioactivity guided studies are required for the identification of bioactive compounds of M.b. albizona venom. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/15569543.2020.1826970
dc.identifier.issn15569543
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13734
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.subjectbaculoviral IAP repeat containing protein 5
dc.subjectcaspase 3
dc.subjectcatalase
dc.subjectHLA DR4 antigen
dc.subjectHLA DR5 antigen
dc.subjectmessenger RNA
dc.subjectprotein
dc.subjectprotein BAD
dc.subjectprotein p53
dc.subjecttumor necrosis factor related apoptosis inducing ligand
dc.subjectvenom
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcell viability
dc.subjectcell viability percentage
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectDU145 cell line
dc.subjectflow cytometry
dc.subjectHEK293 cell line
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmale
dc.subjectmitochondrion
dc.subjectMTT assay
dc.subjectPC-3 [Human prostate carcinoma] cell line
dc.subjectprostate cancer
dc.subjectprotein expression
dc.subjectprotein microarray
dc.subjectreal time polymerase chain reaction
dc.titleProfiling of apoptosis-associated proteins in human prostate cancer cells in response to Montivipera bulgardaghica albizona venom by protein array
dc.typeArticle

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