Cytotoxic, genotoxic, oxidative, and irritant effects of zinc pyrithione in vitro

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dc.contributor.authorGüner A.
dc.contributor.authorİlhan S.
dc.date.accessioned2024-07-22T08:08:00Z
dc.date.available2024-07-22T08:08:00Z
dc.date.issued2020
dc.description.abstractZinc pyrithione is an organometallic compound with antimicrobial activity used in many industrial products. In this study, cytotoxicity (cell viability, lactate dehydrogenase release, proliferation rate, and mitotic index) and genotoxicity (sister chromatid exchange and micronucleus test) of zinc pyrithione on human lymphocytes were determined. Intracellular zinc concentrations were determined by inductively coupled plasma-optical emission spectrometry. Intracellular antioxidant/oxidant status was evaluated by total antioxidant capacity and total oxidative status assays. Its irritation potential was investigated using the hen’s egg test chorioallantoic membrane model. Up to the highest concentration of 1000 nmol/L, ZnPT did not cause genotoxicity and did not change the proliferation index. Above 500 nmol/L, zinc pyrithione caused an increase in lactate dehydrogenase, oxidative stress, and intracellular zinc levels, while decreasing cell viability and mitotic index level. At 1000 nmol/L, zinc pyrithione caused slight irritation. These results suggest that zinc pyrithione may exert toxic effects via increased oxidative stress on human cellular systems. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/02772248.2020.1824258
dc.identifier.issn02772248
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14202
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.subjectInductively coupled plasma
dc.subjectOptical emission spectroscopy
dc.subjectOrganometallics
dc.subjectAnti-microbial activity
dc.subjectChorio-allantoic membranes
dc.subjectInductively coupled plasma-optical emission spectrometry
dc.subjectLactate dehydrogenase
dc.subjectOrganometallic compounds
dc.subjectProliferation index
dc.subjectSister chromatid exchange
dc.subjectTotal antioxidant capacity
dc.subjectantimicrobial activity
dc.subjectantioxidant
dc.subjectcell component
dc.subjectenzyme activity
dc.subjectgenotoxicity
dc.subjectorganometallic compound
dc.subjectoxidative stress
dc.subjectplasma
dc.subjectviability
dc.subjectAntioxidants
dc.titleCytotoxic, genotoxic, oxidative, and irritant effects of zinc pyrithione in vitro
dc.typeArticle

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