The concentration of insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in maternal sera during pregnancy with normal and growth retarded fetuses; [Normal ve yetersiz fetal gelisim gosteren gebelerde gebelik suresince serum insulin benzeri buyume faktoru-1 (IGF-1) ve insulin benzeri buyume faktoru baglayici protein-3 (IGFBP-3) konsantrasyonlari]
No Thumbnail Available
Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: To determine the concentrations of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in maternal sera of pregnancies with normal and growth retarded fetuses and investigate the relationship between these substances and fetal growth. Materials and Methods: Blood samples of 148 pregnant women were collected at 14-16 and 30-31 weeks and during delivery. Also cord blood samples were obtained during delivery. For the determination of IGF-1 and IGFBP-3, double-sided IRMA method was used. Infants were divided into two groups as normal and growth retarded fetuses based upon their patterns of growth using the percentile curves and the serum levels were compared. Correlation analysis and Mann-Whitney U test were used as statistical calculations. Results: Both IGF-1 and IGFBP-3 levels increased while approaching term in all pregnant women. In growth retarded cases, maternal IGF-1 levels were found to be significantly lower than pregnancies with normal fetuses (p< 0.005), but maternal IGFBP-3 levels were not different between two groups. IGF-1 levels in cord blood during delivery were not different while IGFBP-3 levels were significantly higher in growth retarded fetuses. Conclusion: Our study did not support the hypothesis that fetal growth retardation is due to IGF-1 deficiency. High binding protein levels may cause a relative free IGF-1 deficiency, but the levels of binding protein is probably secondary to metabolic changes or placental insufficiency. Low levels of IGF-1 and high levels of binding proteins implies the necessity of further investigation of placental transfer.