Serum brain-derived neurotrophic factor level in dysthymia: A comparative study with major depressive disorder

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dc.contributor.authorAydemir Ö.
dc.contributor.authorDeveci A.
dc.contributor.authorTaskin O.E.
dc.contributor.authorTaneli F.
dc.contributor.authorEsen-Danaci A.
dc.date.accessioned2024-07-22T08:22:49Z
dc.date.available2024-07-22T08:22:49Z
dc.date.issued2007
dc.description.abstractIn this present work, it is aimed to demonstrate BDNF serum concentrations in patients with dysthymia and to compare them with BDNF serum concentrations in patients with major depressive disorder and healthy subjects. The study was carried out in Celal Bayar University Hospital, Manisa, Turkey. Seventeen patients with dysthymia, 24 patients with major depressive disorder and 26 subjects without any psychiatric diagnosis and any psychiatric treatment were included in the study. The severity of depression was assessed with 17-item HAM-D. All subjects were asked to give their written consent. Blood samples were collected at baseline. Serum BDNF was kept at - 70 °C before testing, and assayed with an ELISA Kit (Promega; Madison, WI, USA), after dilution with the Block and Sample solution provided with the kit. The data were subjected to the analysis of variance. The BDNF serum concentrations of the dysthymia group (mean = 28.9 ± 9.2 ng/ml) were significantly higher than that of the major depressive disorder group (21.2 ± 11.3 ng/ml) (p = 0.002), and it was not different from the level of the control group (31.4 ± 8.8 ng/ml). BDNF serum concentrations and HAM-D score did not have any significant correlation in the dysthymia and major depression groups (r = - 0.276, p = 0.086). The low level of BDNF in patients with dysthymic disorder seems to point out that BDNF changes in mood disorders are state-dependent and vary according to the severity of depressive episodes. © 2007 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.pnpbp.2007.02.013
dc.identifier.issn02785846
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19260
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.subjectbrain derived neurotrophic factor
dc.subjectadult
dc.subjectanalysis of variance
dc.subjectarticle
dc.subjectblood sampling
dc.subjectbrain level
dc.subjectclinical article
dc.subjectclinical assessment
dc.subjectcomparative study
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectdisease severity
dc.subjectdysthymia
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectHamilton scale
dc.subjecthuman
dc.subjectinformed consent
dc.subjectmajor depression
dc.subjectmale
dc.subjectmood disorder
dc.subjectpsychiatric diagnosis
dc.subjectpsychiatric treatment
dc.subjectTurkey (republic)
dc.titleSerum brain-derived neurotrophic factor level in dysthymia: A comparative study with major depressive disorder
dc.typeArticle

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