The effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain

Simple item page
dc.contributor.authorGürpinar T.
dc.contributor.authorEkerbiçer N.
dc.contributor.authorUysal N.
dc.contributor.authorBarut T.
dc.contributor.authorTarakçi F.
dc.contributor.authorTuglu M.I.
dc.date.accessioned2024-07-22T08:19:49Z
dc.date.available2024-07-22T08:19:49Z
dc.date.issued2012
dc.description.abstractOxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ,55mg/kg/i.p) in adult rats. MLT was given 10mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat. Copyright © 2012 Tuba Grpnar et al.
dc.identifier.DOI-ID10.1100/2012/498489
dc.identifier.issn1537744X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17864
dc.language.isoEnglish
dc.publisherHindawi Limited
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectmelatonin
dc.subjectnitric oxide synthase
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectbrain
dc.subjectbrain tissue
dc.subjectcerebellum
dc.subjectcontrolled study
dc.subjectdrug activity
dc.subjecthippocampus
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectstreptozocin diabetes
dc.titleThe effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain
dc.typeArticle

Files

Collections

Scopus Koleksiyonu