Electrically conductive borate-based bioactive glass scaffolds for bone tissue engineering applications

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dc.contributor.authorTurk M.
dc.contributor.authorDeliormanll A.M.
dc.date.accessioned2024-07-22T08:10:39Z
dc.date.available2024-07-22T08:10:39Z
dc.date.issued2017
dc.description.abstractIn this study, electrically conductive, borate-based, porous 13-93B3 bioactive glass composite scaffolds were prepared using a polymer foam replication technique. For this purpose, a slurry containing 40 vol% glass particles and 0-10 wt% graphene nanoplatelets was prepared by dispersing the particles in ethanol in the presence of ethyl cellulose. Composite scaffolds were subjected to a controlled heat treatment, in air atmosphere, to decompose the foam and sinter the glass particles into a dense network. It was found that the applied heat treatment did not influence the structure of graphene in the glass network. Graphene additions did not negatively affect the mechanical properties and enhanced the electrical conductivity of the glass scaffolds. In X-ray diffraction analysis, the crystalline peak corresponding to hydroxyapatite was observed in all the samples suggesting that all of the samples were bioactive after 30 days of immersion in simulated body fluid. However, Fourier transform infrared spectroscopy analysis and scanning electron microscope observations revealed that hydroxyapatite formation rate decreased with increasing graphene concentration especially for samples treated in simulated body fluid for shorter times. Based on the cytotoxicity assay findings, the MC3T3-E1 cell growth was significantly inhibited by the scaffolds containing higher amount of graphene compared to bare glass scaffolds. Best performance was obtained for 5 wt% graphene which yielded an enhancement of electrical conductivity with moderate cellular response and in vitro hydroxyapatite forming ability. The study revealed that the electrically conductive 13-93B3 graphene scaffolds are promising candidates for bone tissue engineering applications. © The Author(s) 2017.
dc.identifier.DOI-ID10.1177/0885328217709608
dc.identifier.issn08853282
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15333
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.subjectEngineering
dc.subjectFoam
dc.subjectGlass
dc.subjectPolymers
dc.subjectTissue
dc.subjectAnimals
dc.subjectBone and Bones
dc.subjectBorates
dc.subjectCell Line
dc.subjectCell Proliferation
dc.subjectElectric Conductivity
dc.subjectGlass
dc.subjectGraphite
dc.subjectMaterials Testing
dc.subjectMice, Inbred C57BL
dc.subjectPorosity
dc.subjectStress, Mechanical
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.subjectBiomechanics
dc.subjectBody fluids
dc.subjectBone
dc.subjectElectric conductivity
dc.subjectFoams
dc.subjectFourier transform infrared spectroscopy
dc.subjectGraphene
dc.subjectHeat treatment
dc.subjectHydroxyapatite
dc.subjectScaffolds (biology)
dc.subjectScanning electron microscopy
dc.subjectTissue
dc.subjectTissue engineering
dc.subjectX ray diffraction analysis
dc.subjectalcohol
dc.subjectbioactive glass scaffold
dc.subjectboric acid
dc.subjectethyl cellulose
dc.subjectgraphene
dc.subjecthydroxyapatite
dc.subjectunclassified drug
dc.subjectboric acid
dc.subjectglass
dc.subjectgraphite
dc.subjectBone tissue engineering
dc.subjectElectrical conductivity
dc.subjectElectrically conductive
dc.subjectGraphene nanoplatelets
dc.subjectHydroxyapatite formations
dc.subjectPolymer foams
dc.subjectReplication techniques
dc.subjectTissue engineering applications
dc.subjectanimal cell
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectatmosphere
dc.subjectbiocompatibility
dc.subjectbiological activity
dc.subjectbiomechanics
dc.subjectbody fluid
dc.subjectbone regeneration
dc.subjectbone tissue
dc.subjectcell growth
dc.subjectchemical procedures
dc.subjectchemical structure
dc.subjectcomposite material
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectcytotoxicity assay
dc.subjectdispersion
dc.subjectelectric conductivity
dc.subjectheat treatment
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmersion
dc.subjectinfrared spectroscopy
dc.subjectMC3T3 cell line
dc.subjectmouse
dc.subjectnanofabrication
dc.subjectnonhuman
dc.subjectpolymer foam replication technique
dc.subjectpriority journal
dc.subjectscanning electron microscopy
dc.subjectsimulation
dc.subjecttissue engineering
dc.subjecttissue regeneration
dc.subjecttissue scaffold
dc.subjectX ray diffraction
dc.subjectanimal
dc.subjectbone
dc.subjectC57BL mouse
dc.subjectcell line
dc.subjectcell proliferation
dc.subjectchemistry
dc.subjectcytology
dc.subjectelectric conductivity
dc.subjectmaterials testing
dc.subjectmechanical stress
dc.subjectporosity
dc.subjectprocedures
dc.subjecttissue engineering
dc.subjecttissue scaffold
dc.subjectBioactive glass
dc.titleElectrically conductive borate-based bioactive glass scaffolds for bone tissue engineering applications
dc.typeArticle

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