Evaluation of GCF MMP-1, MMP-8, TGF-β1, PDGF-AB, and VEGF levels in periodontally healthy smokers

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dc.contributor.authorEren G.
dc.contributor.authorTürkoğlu H.O.
dc.contributor.authorAtmaca H.
dc.contributor.authorAtilla F.G.
dc.date.accessioned2024-07-22T08:13:09Z
dc.date.available2024-07-22T08:13:09Z
dc.date.issued2015
dc.description.abstractBackground/aim: The effect of smoking on inflammatory biomarkers in gingival crevicular fluid (GCF) is well established in the presence of periodontal inflammation. However, it is not clear if smoking has an influence on matrix metalloproteinase (MMP) and growth factor levels in the GCF of periodontally healthy subjects. The aim of this study was to investigate GCF levels of MMP-1, MMP8, transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF)-AB, and vascular endothelial growth factor (VEGF) in smoking versus nonsmoking periodontally healthy subjects. Materials and methods: Thirty-two periodontally healthy subjects were included in this study. Probing depths, bleeding on probing, and plaque index was assessed. GCF levels of MMP-1, MMP-8, TGF-β1, PDGF-AB, and VEGF were analyzed by enzyme-linked immunosorbent assay. Results: No significant differences were observed in the distribution of demographic data between study groups. GCF total amount of PDGF-AB was significantly lower in smokers compared to nonsmokers (P = 0.014). Total amount of GCF MMP-1, MMP-8, TGF-β1, and VEGF levels were similar in both study groups (P = 0.022). Conclusion: Smoking has the effect of decreasing GCF PDGF-AB while it does not affect GCF MMP-1, MMP-8, TGF-β1, and VEGF in periodontally healthy subjects. Since increased levels of these molecules are involved in periodontal breakdown, our findings may emphasize the importance for maintenance of periodontal health in smokers. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-1405-112
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16282
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectGingival Crevicular Fluid
dc.subjectHealth Promotion
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectMatrix Metalloproteinase 1
dc.subjectMatrix Metalloproteinase 8
dc.subjectPeriodontal Index
dc.subjectPeriodontitis
dc.subjectPlatelet-Derived Growth Factor
dc.subjectSmoking
dc.subjectTransforming Growth Factor beta1
dc.subjectTurkey
dc.subjectVascular Endothelial Growth Factor A
dc.subjectinterstitial collagenase
dc.subjectneutrophil collagenase
dc.subjectplatelet derived growth factor AB
dc.subjecttransforming growth factor beta1
dc.subjectvasculotropin
dc.subjectinterstitial collagenase
dc.subjectneutrophil collagenase
dc.subjectplatelet derived growth factor
dc.subjectplatelet-derived growth factor AB
dc.subjecttransforming growth factor beta1
dc.subjectvasculotropin A
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgingiva bleeding
dc.subjectgingivitis
dc.subjecthuman
dc.subjectmale
dc.subjectperiodontics
dc.subjectprobing depth
dc.subjectsmoking
dc.subjecttooth plaque
dc.subjectyoung adult
dc.subjectgingivitis
dc.subjecthealth promotion
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectperiodontitis
dc.subjectsmoking
dc.subjectTurkey
dc.titleEvaluation of GCF MMP-1, MMP-8, TGF-β1, PDGF-AB, and VEGF levels in periodontally healthy smokers
dc.typeArticle

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