Samarium-153 therapy for prostate cancer: The evaluation of urine activity, staff exposure and dose rate from patients
No Thumbnail Available
Date
2015
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The aim of this study was to determine the excretion of Samarium-153-ethylenediaminetetramethylphosphonic acid (153Sm- EDTMP) in urine and to calculate the dose rate of its retention in the body as a function of time and the dose received by the skin of laboratory staff 's finger. Urine samples were collected from 11 patients after intravenous injection of 153Sm-EDTMP. The measurements of dose rate were performed. Thermoluminescent dosemeters were used for absorbed dose measurements. Effective half-lives that were calculated from urine sample measurements were found as 7.1±3 h within the first 24 h. Whole body dose rates before collecting urine of patients were 60.0 ± 15.7 μSv h21 for within 1 h following 153Sm-EDTMP administration. The highest finger radiation dose is to the right-hand thumb (3.8 ± 2 mGy). The results of the study imply that patients who recieved 153Sm-EDTMP therapy should be kept a minumum of 8 h in an isolated room at hospital and that one staff should give therapy at most two patients per week. © The Author 2014.
Description
Keywords
Aged , Analgesics, Non-Narcotic , Bone Neoplasms , Humans , Male , Metabolic Clearance Rate , Middle Aged , Occupational Exposure , Organometallic Compounds , Organophosphorus Compounds , Prostatic Neoplasms , Radiation Dosage , Radiopharmaceuticals , Skin , Tissue Distribution , analgesic agent , organometallic compound , organophosphorus compound , radiopharmaceutical agent , samarium ethylenediaminetetramethylenephosphonate , aged , analysis , Bone Neoplasms , human , male , metabolic clearance rate , metabolism , middle aged , occupational exposure , pathology , Prostatic Neoplasms , radiation dose , radiation response , secondary , skin , tissue distribution , urine