Subclinical hypothyroidism: Comparison of adhesion molecule levels before and after levothyroxine therapy
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2014
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Abstract
Objective: Adhesion molecules are involved in inflammation, atherosclerosis and malignancy. This study measured levels of adhesion molecules before and after levothyroxine therapy in patients with subclinical hypothyroidism (SHO). Methods: Levels of soluble (s) intracellular adhesion molecule (ICAM)-1, s vascular cell adhesion molecule (sVCAM) VCAM-1 and sE-selectin were analysed in patients diagnosed with SHO, prior to administration of 50 mg/day levothyroxine orally for 3 months. Subsequently, levels of sICAM-1, sVCAM-1 and sE-selectin were reanalysed then compared with the pretreatment levels. Results: In 30 patients with SHO, levels of sICAM-1 were found to be significantly higher than those in healthy controls, (P=0.001). Post-treatment sICAM-1 levels were significantly lower than pretreatment levels (P=0.001). No significant differences were found in sVCAM-1 or sE-selectin levels between healthy controls and patients with SHO before treatment, or between patients with SHO pre- and post-treatment. Conclusions: Patients with SHO had significantly higher levels of sICAM-1 compared with controls. Levels became normal after treatment with levothyroxine. These findings emphasize the need for levothyroxine therapy in cases of SHO to normalize sICAM-1 levels. Such treatment helps to prevent the future development of atherosclerosis or cancer. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
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Adult , Asymptomatic Diseases , Case-Control Studies , Drug Administration Schedule , E-Selectin , Female , Humans , Hypothyroidism , Intercellular Adhesion Molecule-1 , Male , Middle Aged , Thyrotropin , Thyroxine , Treatment Outcome , Triiodothyronine , Vascular Cell Adhesion Molecule-1 , endothelial leukocyte adhesion molecule 1 , intercellular adhesion molecule 1 , levothyroxine , liothyronine , thyrotropin , thyroxine , vascular cell adhesion molecule 1 , endothelial leukocyte adhesion molecule 1 , ICAM1 protein, human , intercellular adhesion molecule 1 , liothyronine , thyrotropin , thyroxine , vascular cell adhesion molecule 1 , adult , article , clinical article , comparative study , controlled study , fatigue , female , free thyroxine index , Hashimoto disease , human , immunoassay analyzer , liothyronine blood level , male , morbidity , subclinical hypothyroidism , thyrotropin blood level , treatment duration , weight gain , asymptomatic disease , blood , case control study , drug administration , hypothyroidism , middle aged , treatment outcome