A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey

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dc.contributor.authorDurdu M.
dc.contributor.authorBozca B.C.
dc.contributor.authorEnli S.
dc.contributor.authorYazıcı Özgen Z.
dc.contributor.authorYaylı S.
dc.contributor.authorAktan Ş.
dc.contributor.authorMutlu D.
dc.contributor.authorErturan I.
dc.contributor.authorAyvaz Çelik H.H.
dc.contributor.authorMelikoğlu M.
dc.contributor.authorPala E.
dc.contributor.authorGürsel Ürün Y.
dc.contributor.authorHarman M.
dc.contributor.authorŞavk E.
dc.contributor.authorIşık S.
dc.contributor.authorDuygulu Ş.
dc.contributor.authorİmren I.G.
dc.contributor.authorFettahlıoğlu Karaman B.
dc.contributor.authorKaya Erdoğan H.
dc.contributor.authorKılıç A.
dc.contributor.authorÖzçelik S.
dc.contributor.authorInan K.
dc.contributor.authorYılmaz M.A.
dc.contributor.authorŞanlı H.E.
dc.contributor.authorKalay Yıldızhan İ.
dc.contributor.authorMülayim M.K.
dc.contributor.authorÇiçek D.
dc.contributor.authorDemir B.
dc.contributor.authorYasak Güner R.
dc.contributor.authorBaykal Selçuk L.
dc.contributor.authorGündüz K.
dc.contributor.authorDaye M.
dc.contributor.authorBorlu M.
dc.contributor.authorSolak E.O.
dc.contributor.authorDizman D.
dc.contributor.authorGüneş B.
dc.contributor.authorOzkur E.
dc.contributor.authorPolat M.
dc.contributor.authorEskiocak A.H.
dc.contributor.authorUzun S.
dc.date.accessioned2024-07-22T08:05:24Z
dc.date.available2024-07-22T08:05:24Z
dc.date.issued2021
dc.description.abstractBackground: The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods: We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results: A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions: This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase. © 2021 The Australasian College of Dermatologists
dc.identifier.DOI-ID10.1111/ajd.13731
dc.identifier.issn00048380
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13123
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Distribution
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPemphigoid, Bullous
dc.subjectPemphigus
dc.subjectProspective Studies
dc.subjectSex Distribution
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectdipeptidyl peptidase IV inhibitor
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbullous pemphigoid
dc.subjectcardiovascular disease
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdemography
dc.subjectdiagnostic procedure
dc.subjectenzyme linked immunosorbent assay
dc.subjectepidermolysis bullosa
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunofluorescence
dc.subjectincidence
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmucous membrane pemphigoid
dc.subjectmulticenter study
dc.subjectneurologic disease
dc.subjectpemphigoid
dc.subjectpemphigoid gestationis
dc.subjectprospective study
dc.subjectskin biopsy
dc.subjecttertiary care center
dc.subjectTurkey (republic)
dc.subjectvery elderly
dc.subjectadolescent
dc.subjectage distribution
dc.subjectbullous pemphigoid
dc.subjectchild
dc.subjectclinical trial
dc.subjectincidence
dc.subjectpemphigus
dc.subjectpreschool child
dc.subjectsex ratio
dc.subjectturkey (bird)
dc.subjectyoung adult
dc.titleA multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
dc.typeArticle

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