Necrotising fasciitis: Clinical evaluation and treatment results of 18 patients; [Nekrotizan Fasiit: 18 Hastanın Klinik Durumlarının ve Tedavi Sonuçlarının Değerlendirilmesi]

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dc.contributor.authorÖztürk A.M.
dc.contributor.authorSüer O.
dc.contributor.authorErdem H.A.
dc.contributor.authorYildirim Şimşir I.
dc.contributor.authorŞenol Akar Ş.
dc.contributor.authorÖzkayin N.
dc.contributor.authorIşikgöz Taşbakan M.
dc.contributor.authorAkyol D.
dc.date.accessioned2024-07-22T08:08:42Z
dc.date.available2024-07-22T08:08:42Z
dc.date.issued2019
dc.description.abstractIntroduction: Necrotizing fasciitis (NF) is a complicated and rapidly spreading soft tissue infection that affects the superficial fascia, skin, and subcutaneous tissue. In this study, we evaluated patients who were diagnosed with NF and treated in two tertiary-care educational university hospitals. Materials and Methods: Patients diagnosed with NF in three centers (Ege University Department of Orthopedics and Traumatology and Department of Infectious Diseases and Clinical Microbiology and Celal Bayar University Department of Infectious Diseases and Clinical Microbiology) between November 2016 and December 2018 were retrospectively analyzed. The patients’ demographic characteristics, significant risk factors for infection, sites of infection, models of surgical treatment, department(s) that performed the surgery, causative infectious agents, empirical and agent-specific treatment regimens and their duration, length of hospital stay, need for intensive care, and one month survival were evaluated. Results: Eighteen patients (10 females, mean age 53.7 [19-86 years]) who were diagnosed with NF were included in the study. Diabetes mellitus, trauma/surgery history, and decubitus wound were the most common predisposing factors. The most common anatomic site was lower extremity (n=10, 55.5%). All patients underwent surgical debridement. The most commonly isolated microorganisms were Escherichia coli (n=4), Klebsiella pneumoniae, Proteus mirabilis, and Acinetobacter baumannii (each n=3). Empirical treatment was initiated with meropenem in eight patients (32%) and tigecycline in four patients (12.5%), and the antibiotic was changed in five patients based on culture results. The mean duration of antibiotic therapy was 35.5 (9-68) days. The average hospital stay was 55 (11-186) days. Six patients (33.3%) required intensive care during followup. The mortality rate was 16.6%. Conclusion: NF is a fulminant disease, and early diagnosis and effective multidisciplinary treatment are crucial for reducing mortality rates. When the diagnosis is suspected, early surgical debridement should be performed and empirical antibiotherapy should be started immediately. ©Copyright 2019 by the Infectious Diseases and Clinical Microbiology Specialty Society of Turkey.
dc.identifier.DOI-ID10.4274/mjima.galenos.2019.2019.9
dc.identifier.issn2147673X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14486
dc.language.isoEnglish
dc.publisherGalenos
dc.rightsAll Open Access; Gold Open Access
dc.subjectamikacin
dc.subjectC reactive protein
dc.subjectceftriaxone
dc.subjectciprofloxacin
dc.subjectclindamycin
dc.subjectcolistin
dc.subjectdaptomycin
dc.subjectertapenem
dc.subjectlinezolid
dc.subjectmeropenem
dc.subjectmetronidazole
dc.subjectpiperacillin plus tazobactam
dc.subjectsultamicillin
dc.subjectteicoplanin
dc.subjecttigecycline
dc.subjectAcinetobacter baumannii
dc.subjectadult
dc.subjectaged
dc.subjectantibiotic resistance
dc.subjectantibiotic therapy
dc.subjectArticle
dc.subjectclinical article
dc.subjectclinical evaluation
dc.subjectdisease duration
dc.subjectEscherichia coli
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectinfection risk
dc.subjectintensive care
dc.subjectKlebsiella pneumoniae
dc.subjectlength of stay
dc.subjectleukocyte count
dc.subjectmale
dc.subjectmortality rate
dc.subjectnecrotizing fasciitis
dc.subjectProteus mirabilis
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectsurgical debridement
dc.subjecttertiary health care
dc.subjecttreatment duration
dc.subjectuniversity hospital
dc.titleNecrotising fasciitis: Clinical evaluation and treatment results of 18 patients; [Nekrotizan Fasiit: 18 Hastanın Klinik Durumlarının ve Tedavi Sonuçlarının Değerlendirilmesi]
dc.typeArticle

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