Levosimendan up-regulates transforming growth factor-beta and smad signaling in the aorta in the early stage of sepsis; [Levosimendan erken dönem sepsiste aortada "transforming growth factor beta" ve Smad işaretlenmesini up-regüle eder]

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dc.contributor.authorErbüyün K.
dc.contributor.authorTok D.
dc.contributor.authorVatansever S.
dc.contributor.authorOk G.
dc.contributor.authorTürköz E.
dc.contributor.authorAydede H.
dc.contributor.authorErhan Y.
dc.contributor.authorTekin I.
dc.date.accessioned2024-07-22T08:21:13Z
dc.date.available2024-07-22T08:21:13Z
dc.date.issued2010
dc.description.abstractBACKGROUND This prospective, controlled experimental study was planned to investigate the effects of levosimendan on transforming growth factor (TGF)-β3 and Smad1, Smad2 and Smad3 expression in the early stages of sepsis. METHODS Twenty-four rats were randomized into four groups: 1) sham-operated controls, 2) dobutamine group - subjected to abdominal hypertension and peritonitis-induced sepsis using cecal ligation and puncture (CLP), then treated with 10 μg.kg-1min-1 intravenous (IV) dobutamine infusion, 3) levosimendan group - as in 2, then treated with levosimendan IV bolus 200 μg.kg-1 followed by 200 μg.kg.-1 min-1 IV infusion, and 4) a control group as in 2, with no treatment. All rats were killed 8 hours after CLP. Aorta tissue samples were analyzed by immunohistochemical staining. RESULTS CLP caused mild interleukin (IL)-1 immunostaining in both control and dobutamine groups. Immunoreactivity of tumor necrosis factor (TNF)-α was mild in both sham and control groups. TGF-β3 immunostaining was mildly increased in groups sham, control and dobutamine, whereas it was found moderate in group levosimendan. Smad1, Smad2 and Smad3 were found moderately increased only in group levosimendan. CONCLUSION Beneficial effects of levosimendan on hemodynamics and global oxygen transport were reported in experimental and clinical trials. Besides its potency on C++ ion sensitivity, it should influence inflammatory cytokine production by diminishing TGF-β3 and Smad1, Smad2 and Smad3 expression.
dc.identifier.issn1306696X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18515
dc.language.isoTurkish
dc.publisherTurkish Association of Trauma and Emergency Surgery
dc.subjectAnimals
dc.subjectAorta
dc.subjectBlood Pressure
dc.subjectDopamine
dc.subjectHydrazones
dc.subjectMale
dc.subjectPyridazines
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSepsis
dc.subjectSmad1 Protein
dc.subjectSmad2 Protein
dc.subjectSmad3 Protein
dc.subjectTransforming Growth Factor beta3
dc.subjectTumor Necrosis Factor-alpha
dc.subjectVasodilator Agents
dc.subjectdobutamine
dc.subjectinterleukin 1
dc.subjectlevosimendan
dc.subjectSmad protein
dc.subjectSmad1 protein
dc.subjectSmad2 protein
dc.subjectSmad3 protein
dc.subjecttransforming growth factor beta
dc.subjectdopamine
dc.subjecthydrazone derivative
dc.subjectMadh2 protein, rat
dc.subjectMadh3 protein, rat
dc.subjectpyridazine derivative
dc.subjectsimendan
dc.subjectSmad1 protein
dc.subjectSmad1 protein, rat
dc.subjectSmad2 protein
dc.subjectSmad3 protein
dc.subjecttransforming growth factor beta3
dc.subjecttumor necrosis factor alpha
dc.subjectvasodilator agent
dc.subjectaorta
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectnonhuman
dc.subjectrat
dc.subjectsepsis
dc.subjectanimal
dc.subjectblood pressure
dc.subjectdrug effects
dc.subjectgenetics
dc.subjectmale
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectsepsis
dc.subjectWistar rat
dc.titleLevosimendan up-regulates transforming growth factor-beta and smad signaling in the aorta in the early stage of sepsis; [Levosimendan erken dönem sepsiste aortada "transforming growth factor beta" ve Smad işaretlenmesini up-regüle eder]
dc.typeArticle

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