Association between neutrophil-lymphocyte & platelet lymphocyte ratios with prognosis & mortality in rapidly progressive glomerulonephritis

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dc.contributor.authorToraman A.
dc.contributor.authorNeşe N.
dc.contributor.authorÖzyurt B.
dc.contributor.authorKürşat S.
dc.date.accessioned2024-07-22T08:08:17Z
dc.date.available2024-07-22T08:08:17Z
dc.date.issued2019
dc.description.abstractBackground & objectives: Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by features of nephritic syndrome and progressive loss of renal function over a short time. The objective of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic factors and pathological findings of renal biopsy in RPGN. Methods: Consecutive newly diagnosed RPGN patients who had follow up for at least six months were retrospectively analyzed. The estimated glomerular filtration rate (EGFR) was calculated. Albumin, C-reactive protein (CRP) levels and CRP/albumin ratio were also calculated. Results: Fifty four patients were included in the study. The mean age was 48.92±20.12 years. Clinicopathological diagnosis was pauci-immune glomerulonephritis (GN) in 40 while two had postinfectious GN, six systemic lupus erythematosus, three IgA nephropathy, two Henoch-Schönlein purpura and one membranoproliferative GN. The mean NLR was 7.02±6.34 and mean PLR was 273.90±39.15. Positive correlations between NLR and CRP levels (P=0.009, r=0.511) and CRP/albumin ratios (P=0.005, r=0.542) were observed. PLR and CRP/albumin ratios (P=0.041, r=0.412) were correlated positively. The per cent of fibrocellular crescents was negatively correlated with NLR (P=0.019, r=-0.291), and positively correlated with the lymphocyte count (P=0.05, r=0.256). In secondary crescentic subgroup, the per cent of fibrinoid necrosis had a positive correlation with PLR (P=0.013, r=0.642). Both NLR (P=0.036) and PLR (P=0.051) detected at the first month of the treatment period, were observed to be significantly correlated with mortality. Interpretation & conclusions: This study showed that NLR could predict mortality in patients with RPGN; correlated with systemic inflammation; showed a negative correlation with the per cent of fibrocellular crescents and could be regarded as a measure of glomerular inflammatory state. Moreover, PLR may be considered to be an indicator of disease severity in acute phase of crescentic GN. © 2019 Indian Journal of Medical Research.
dc.identifier.DOI-ID10.4103/ijmr.IJMR_1234_17
dc.identifier.issn09715916
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14332
dc.language.isoEnglish
dc.publisherWolters Kluwer Medknow Publications
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectC-Reactive Protein
dc.subjectFemale
dc.subjectGlomerulonephritis
dc.subjectHumans
dc.subjectKidney
dc.subjectLeukocyte Count
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeutrophils
dc.subjectPlatelet Count
dc.subjectPrognosis
dc.subjectalbumin
dc.subjectC reactive protein
dc.subjectcorticosteroid
dc.subjectcreatinine
dc.subjectcyclophosphamide
dc.subjectferritin
dc.subjectneutrophil cytoplasmic antibody
dc.subjectsodium
dc.subjectglucose
dc.subjectC reactive protein
dc.subjectadult
dc.subjectalbumin blood level
dc.subjectanaphylactoid purpura
dc.subjectantibody blood level
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcorticosteroid therapy
dc.subjectcreatinine blood level
dc.subjectdisease association
dc.subjectestimated glomerular filtration rate
dc.subjectfemale
dc.subjectferritin blood level
dc.subjectfollow up
dc.subjecthematocrit
dc.subjecthemodialysis
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunofluorescence
dc.subjectimmunoglobulin A nephropathy
dc.subjectkidney biopsy
dc.subjectkidney necrosis
dc.subjectlymphocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmembranoproliferative glomerulonephritis
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectneutrophil lymphocyte ratio
dc.subjectplatelet lymphocyte ratio
dc.subjectprognosis
dc.subjectprotein blood level
dc.subjectrapidly progressive glomerulonephritis
dc.subjectremission
dc.subjectretrospective study
dc.subjectsodium blood level
dc.subjectsystemic lupus erythematosus
dc.subjectWegener granulomatosis
dc.subjectclinical outcome
dc.subjectdiastolic blood pressure
dc.subjectdisease activity
dc.subjectdisease severity
dc.subjectglomerulonephritis
dc.subjecthematological parameters
dc.subjecthematuria
dc.subjecthemoglobin blood level
dc.subjecthistopathology
dc.subjectimmunofluorescence test
dc.subjectinfection complication
dc.subjectinflammation
dc.subjectkidney function
dc.subjectleukocyte count
dc.subjectmortality rate
dc.subjectneutrophil count
dc.subjectplatelet count
dc.subjectpredictive value
dc.subjectproteinuria
dc.subjectrapidly progressive glomerulonephritis
dc.subjectsystolic blood pressure
dc.subjecttreatment duration
dc.subjecttreatment response
dc.subjecturea nitrogen blood level
dc.subjectaged
dc.subjectblood
dc.subjectglomerulonephritis
dc.subjectkidney
dc.subjectleukocyte count
dc.subjectlymphocyte
dc.subjectmortality
dc.subjectneutrophil
dc.subjectpathology
dc.subjectplatelet count
dc.titleAssociation between neutrophil-lymphocyte & platelet lymphocyte ratios with prognosis & mortality in rapidly progressive glomerulonephritis
dc.typeArticle

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