Safety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature

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dc.contributor.authorToprak-Kanık E.
dc.contributor.authorYılmaz Ö.
dc.contributor.authorYangın-Ergon E.
dc.contributor.authorTürkeli A.
dc.contributor.authorYüksel H.
dc.date.accessioned2024-07-22T08:10:08Z
dc.date.available2024-07-22T08:10:08Z
dc.date.issued2018
dc.description.abstractSubcutaneous allergen immunotherapy (SCIT) has been shown to improve clinical course in children with asthma and allergic rhinitis (AR). Systemic and local side-effects may be seen during its administration. The purpose of this study was to evaluate risk factors associated with systemic and local side-effects in children receiving SCIT. We performed a retrospective chart review in the children who received allergen subcutaneous immunotherapy for asthma and/or allergen rhinitis. Demographic data, diagnosis, skin prick test results, presence of additional allergic diseases, the seasonal variation of adverse events in the first and third years of SCIT were recorded. A total of 508 eligible patients were included in the study. Mean age of the children was 10.9±3.2 years, and 65.4% were male. Asthma was present in 21.9% of the children, AR in 44.7%, 33.5% of them had both asthma and AR. According to the skin prick test results, sensitivity to more than one allergen was present in 45.1%, while the most common single-allergen sensitivities were to grass pollen and dermatophagoids (32.5% and 14.4%, respectively). Ratio of systemic and local side-effects was 4.7% and 9.3%, respectively. Local side-effects were more common than systemic reaction. SCIT is a safe treatment modality while using the appropriate dose and with the administration of dose-escalation protocol. © 2018, Turkish Journal of Pediatrics. All rights reserved.
dc.identifier.DOI-ID10.24953/turkjped.2018.06.009
dc.identifier.issn00414301
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15080
dc.language.isoEnglish
dc.publisherTurkish Journal of Pediatrics
dc.rightsAll Open Access; Bronze Open Access
dc.subjectallergen
dc.subjectimmunomodulating agent
dc.subjectadult
dc.subjectallergic rhinitis
dc.subjectArticle
dc.subjectasthma
dc.subjectchild
dc.subjectdesensitization
dc.subjectdrug hypersensitivity
dc.subjectdrug safety
dc.subjectfemale
dc.subjectgender
dc.subjecthouse dust allergy
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpollen allergy
dc.subjectprick test
dc.subjectretrospective study
dc.subjectseasonal variation
dc.titleSafety of subcutaneous allergen immunotherapy in children: A retrospective review and bird eye to literature
dc.typeArticle

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