Investigation of effect of Vitamin D receptor, calcium-sensing receptor and β-catenin on cutaneous squamous cell carcinoma; [D vitamini reseptörü, kalsiyuma duyarlı reseptör ve β-katenin'in skuamöz hücreli deri kanseri üzerine etkisinin araştırılması]

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dc.contributor.authorTuğrul B.
dc.contributor.authorSöylev S.
dc.contributor.authorTemiz P.
dc.contributor.authorGençoğlan G.
dc.date.accessioned2024-07-22T08:08:02Z
dc.date.available2024-07-22T08:08:02Z
dc.date.issued2020
dc.description.abstractBackground: Cutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (β-catenin) proteins have an effect on cSCC. Materials and methods: VDR, CaSR and β-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated. Results: IHC staining density of VDR and β-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and β-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and β-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown. Conclusion: The findings suggest that VDR and β-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and β-catenin together on cSCC. © 2020 De Gruyter. All rights reserved.
dc.identifier.DOI-ID10.1515/tjb-2019-0434
dc.identifier.issn02504685
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14226
dc.language.isoEnglish
dc.publisherDe Gruyter
dc.rightsAll Open Access; Gold Open Access
dc.subjectbeta catenin
dc.subjectcalcium sensing receptor
dc.subjectvitamin D receptor
dc.subjectArticle
dc.subjectcontrolled study
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectpolyacrylamide gel electrophoresis
dc.subjectprotein analysis
dc.subjectprotein determination
dc.subjectprotein localization
dc.subjectskin carcinoma
dc.subjectsquamous cell carcinoma
dc.subjectstaining
dc.subjectWestern blotting
dc.titleInvestigation of effect of Vitamin D receptor, calcium-sensing receptor and β-catenin on cutaneous squamous cell carcinoma; [D vitamini reseptörü, kalsiyuma duyarlı reseptör ve β-katenin'in skuamöz hücreli deri kanseri üzerine etkisinin araştırılması]
dc.typeArticle

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