A rare familial thrombocytopenia: May-Hegglin anomaly report of two cases and review of the literature

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dc.contributor.authorGülen H.
dc.contributor.authorErbay A.
dc.contributor.authorKazanci E.
dc.contributor.authorVergin C.
dc.date.accessioned2024-07-22T08:23:14Z
dc.date.available2024-07-22T08:23:14Z
dc.date.issued2006
dc.description.abstractMay-Hegglin anomaly is a hereditary thrombocytopenia associated with giant platelets and large basophilic, cytoplasmic inclusion bodies (resembling Döhle bodies) in the granulocytes. Patients may experience easy bruising, recurrent epistaxis, gingival bleeding, menorrhagia and sometimes excessive bleeding associated with surgical procedures. Failure to appropriately diagnose May-Hegglin anomaly could result in inappropriate treatment. In states of chronic thrombocytopenia associated with large platelets, including chronic idiopathic thrombocytopenic purpura, May-Hegglin anomaly should be considered in the differential diagnosis. In this case report, we present a five-year-old girl previously followed as idiopathic thrombocytopenic purpura without bleeding symptoms and a 14-year-old boy who were diagnosed with May-Hegglin anomaly. © Turkish Society of Hematology.
dc.identifier.issn13007777
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19446
dc.language.isoEnglish
dc.subjectmethylprednisolone
dc.subjectpenicillin G
dc.subjectadolescent
dc.subjectarticle
dc.subjectautosomal dominant inheritance
dc.subjectbasophil
dc.subjectblood cell count
dc.subjectblood smear
dc.subjectcase report
dc.subjectcell inclusion
dc.subjectclinical feature
dc.subjectcomputer assisted tomography
dc.subjectdiagnostic error
dc.subjectdrug megadose
dc.subjectecchymosis
dc.subjectfamilial disease
dc.subjectfemale
dc.subjecthuman
dc.subjectidiopathic thrombocytopenic purpura
dc.subjectincidental finding
dc.subjectlaboratory test
dc.subjectleukocyte
dc.subjectlung infiltrate
dc.subjectlung sarcoidosis
dc.subjectlymph node biopsy
dc.subjectlymphadenopathy
dc.subjectmale
dc.subjectMay Hegglin anomaly
dc.subjectphysical examination
dc.subjectpreschool child
dc.subjectthorax radiography
dc.subjectthrombocyte shape
dc.subjectthrombocytopenia
dc.titleA rare familial thrombocytopenia: May-Hegglin anomaly report of two cases and review of the literature
dc.typeArticle

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