The role of prothrombotic factors in children with hemiplegic cerebral palsy

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dc.contributor.authorTüredi Yildirim A.
dc.contributor.authorSütçü R.
dc.contributor.authorKöroğlu M.
dc.contributor.authorDelibaş N.
dc.contributor.authorKişioğlu N.
dc.contributor.authorAkar N.
dc.contributor.authorErgürhan İlha I.
dc.date.accessioned2024-07-22T08:13:00Z
dc.date.available2024-07-22T08:13:00Z
dc.date.issued2015
dc.description.abstractAIM: Hemiplegic cerebral palsy (HCP) is a condition occurring as a consequence of a non-progressive damage of the brain with incomplete anatomical and physical development during the early period of life. Its etiology is multifactorial, with the cause remaining unexplained in the majority of cases. This study aims to investigate whether thrombophilic factors correlates with the etiology in children with HCP.; METHODS: We included 36 children with HCP in the patient group, and 41 healthy children with no neurologic disorders in the control group. No significant difference was found between the two groups in terms of factor V leiden, methylenetetrahydrofolate reductase and prothrombin 20210A mutation frequency and protein C, protein S and antithrombin III levels.; RESULTS: Homocysteine levels were significantly higher in the group of patients with HCP as compared to the control group (P=0.012). Because we could not identify the origin of hyperhomocysteinemia as congenital or acquired, the impact of hyperhomocysteinemia on HCP was considered insignificant. Each thrombophilic disorder was assessed in terms of relatedness to atrophy, periventricular leukomalacia, infarct, congenital anomaly and porencephalic cyst, respectively. No significant correlation was detected between thrombophilic disorders and cranial imaging findings.; CONCLUSION: Our study has shown that thrombophilic factors are not involved in the etiology of HCP.
dc.identifier.issn18271715
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16256
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectCase-Control Studies
dc.subjectCerebral Palsy
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHemiplegia
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectMale
dc.subjectMethylenetetrahydrofolate Reductase (NADPH2)
dc.subjectThrombophilia
dc.subjecthomocysteine
dc.subjectmethylenetetrahydrofolate reductase (NADPH2)
dc.subjectadolescent
dc.subjectblood
dc.subjectcase control study
dc.subjectcerebral palsy
dc.subjectchild
dc.subjectcomplication
dc.subjectfemale
dc.subjecthemiplegia
dc.subjecthuman
dc.subjectmale
dc.subjectpathophysiology
dc.subjectpreschool child
dc.subjectthrombophilia
dc.titleThe role of prothrombotic factors in children with hemiplegic cerebral palsy
dc.typeArticle

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