The evaluation of pretreatment neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms; [Avaliação da relação neutrófilo-linfócito e relação neutrófilo-linfócito derivada no pré-tratamento em pacientes com neoplasias laríngeas]

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dc.contributor.authorEskiizmir G.
dc.contributor.authorUz U.
dc.contributor.authorOnur E.
dc.contributor.authorOzyurt B.
dc.contributor.authorKaraca Cikrikci G.
dc.contributor.authorSahin N.
dc.contributor.authorOran A.
dc.contributor.authorCelik O.
dc.date.accessioned2024-07-22T08:08:29Z
dc.date.available2024-07-22T08:08:29Z
dc.date.issued2019
dc.description.abstractIntroduction: Systemic inflammatory biomarkers are promising predictive and prognostic factors for solid cancers. The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio are used to predict inflammation and used as biomarker in several malignancies. Objective: The purpose of this study was to demonstrate the diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms. Methods: A retrospective study was conducted on medical records involving 229 patients with benign, premalignant and malignant laryngeal neoplasms between 2002 and 2015. The diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were evaluated using uni– and multivariate analysis. Results: The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were not statistically different between patients with benign, premalignant and malignant laryngeal neoplasms. Both neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were predictive factors for stage, lymph node metastasis, and distant metastasis. Patients with high neutrophil–lymphocyte ratio value (≥4) had a poor prognosis when compared with patients with low neutrophil–lymphocyte ratio value (5 year, Overall Survival: 69.0% vs. 31.1%, p < 0.001; 5 year, disease free survival: 70.0% vs. 32.7%, p ˂ 0.001; 5 year, locoregional recurrence free survival: 69.7% vs. 32.0%, p < 0.001). Furthermore, neutrophil–lymphocyte ratio was an independent prognostic factor for 5 year: Overall survival (HR = 2.396; 95% CI 1.408–4.077; p = 0.001), Disease free survival (HR = 2.246; 95% CI 1.322–3.816; p = 0.006) and locoregional recurrence free survival (HR = 2.210; 95% CI 1.301–3.753; p = 0.003). Conclusion: Pretreatment neutrophil–lymphocyte ratio is a useful and reliable predictive and prognostic biomarker for patients with laryngeal carcinoma. © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
dc.identifier.DOI-ID10.1016/j.bjorl.2018.04.013
dc.identifier.issn18088694
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14411
dc.language.isoEnglish
dc.publisherElsevier Editora Ltda
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomarkers, Tumor
dc.subjectCarcinoma, Squamous Cell
dc.subjectDisease Progression
dc.subjectDisease-Free Survival
dc.subjectFemale
dc.subjectHumans
dc.subjectLaryngeal Neoplasms
dc.subjectLymphocyte Count
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Recurrence, Local
dc.subjectNeoplasm Staging
dc.subjectNeutrophils
dc.subjectPredictive Value of Tests
dc.subjectPreoperative Care
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjecttumor marker
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbenign neoplasm
dc.subjectcancer diagnosis
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectderived neutrophil lymphocyte ratio
dc.subjectdisease free survival
dc.subjectdistant metastasis
dc.subjectdysplasia
dc.subjectfemale
dc.subjecthuman
dc.subjectlarynx tumor
dc.subjectlocal recurrence free survival
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalignant neoplasm
dc.subjectmedical record
dc.subjectmedical record review
dc.subjectneutrophil lymphocyte ratio
dc.subjectoverall survival
dc.subjectretrospective study
dc.subjectvocal cord disorder
dc.subjectvocal fold nodule
dc.subjectvocal fold polyp
dc.subjectblood
dc.subjectcancer staging
dc.subjectdisease exacerbation
dc.subjectlarynx tumor
dc.subjectlymphocyte count
dc.subjectmiddle aged
dc.subjectneutrophil
dc.subjectpathology
dc.subjectpredictive value
dc.subjectpreoperative care
dc.subjectprognosis
dc.subjectsquamous cell carcinoma
dc.subjecttumor recurrence
dc.subjectvery elderly
dc.titleThe evaluation of pretreatment neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms; [Avaliação da relação neutrófilo-linfócito e relação neutrófilo-linfócito derivada no pré-tratamento em pacientes com neoplasias laríngeas]
dc.typeArticle

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