Bone marrow radiation dosimetry of high dose 131I treatment in differentiated thyroid carcinoma patients

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dc.contributor.authorParlak Y.
dc.contributor.authorDemir M.
dc.contributor.authorCavdar I.
dc.contributor.authorEreees S.
dc.contributor.authorGumuser G.
dc.contributor.authorUysal B.
dc.contributor.authorKaya G.C.
dc.contributor.authorKoç M.
dc.contributor.authorSayit E.
dc.date.accessioned2024-07-22T08:11:59Z
dc.date.available2024-07-22T08:11:59Z
dc.date.issued2016
dc.description.abstractBackground: Radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloablative therapies. The aim of this study was to calculate bone marrow radiation dose by using MIRDOSE3 package program and to optimize the safe limit of acivity to be administered to the thyroid cancer paients. Materials and Methods: In this study, 83 thyroid cancer patients were divided into 3 groups based on the amount of acivity administered into the body. In the groups, 3700 MBq, 5550 MBq and 7400 MBq activities were used respecively. The curves of ime-acivity were drawn from blood samples counts and effective half-life and residence time were calculated. Correlations of bone marrow radiation dose and radioiodine effective half-life were determined as a function of administered activity via ANOVA test. Tg levels and tumour diameters were compared using Spearman's correlation. Results: The effective half-lives of 131I for three groups of whole-body, receiving 3700 MBq, 5550 MBq and 7400 MBq were calculated as 20.57±5.4, 17.8±5.8 and 18.7±3.9 hours, respectively. The average bone marrow doses for 3 groups of patients were 0.32±0.08 Gy, 0.42±0.14 Gy and 0.60±0.24 Gy, respectively. Conclusion: It was concluded that, the bone marrow dose to the patients still remains within the recommended level even after administering an activity of 7400 MBq of 131I to the patients.
dc.identifier.DOI-ID10.18869/acadpub.ijrr.14.2.99
dc.identifier.issn23223243
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15870
dc.language.isoEnglish
dc.publisherNovin Medical Radiation Institute
dc.rightsAll Open Access; Bronze Open Access
dc.subjectiodine 131
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectblood sampling
dc.subjectbone marrow
dc.subjectcancer patient
dc.subjectcorrelational study
dc.subjectdifferentiated thyroid cancer
dc.subjectdosimetry
dc.subjectdrug half life
dc.subjectdrug megadose
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectradiation dose
dc.titleBone marrow radiation dosimetry of high dose 131I treatment in differentiated thyroid carcinoma patients
dc.typeArticle

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