Prevention of posterior capsule opacification by retinoic acid and mitomycin

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dc.contributor.authorInan, ÜÜ
dc.contributor.authorÖztürk, F
dc.contributor.authorKaynak, S
dc.contributor.authorIlker, SS
dc.contributor.authorÖzer, E
dc.contributor.authorGüler, C
dc.date.accessioned2025-04-10T10:35:44Z
dc.date.available2025-04-10T10:35:44Z
dc.description.abstractBackground: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 mug/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P <0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multilayer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation.
dc.identifier.e-issn1435-702X
dc.identifier.issn0721-832X
dc.identifier.urihttp://hdl.handle.net/20.500.14701/41721
dc.language.isoEnglish
dc.titlePrevention of posterior capsule opacification by retinoic acid and mitomycin
dc.typeArticle; Proceedings Paper

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