A nationwide retrospective study in Turkish children with nephrocalcinosis

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dc.contributor.authorDöven S.S.
dc.contributor.authorTülpar S.
dc.contributor.authorBaştuğ F.
dc.contributor.authorYıldırım Z.N.Y.
dc.contributor.authorYılmaz E.K.
dc.contributor.authorÇiçek N.
dc.contributor.authorKüçük N.
dc.contributor.authorÇomak E.
dc.contributor.authorYazıcıoğlu B.
dc.contributor.authorNalçacıoğlu H.
dc.contributor.authorDelibaş A.
dc.contributor.authorUysal B.
dc.contributor.authorAğbaş A.
dc.contributor.authorGemici A.
dc.contributor.authorGünay N.
dc.contributor.authorErtan P.
dc.contributor.authorBıyıklı N.
dc.contributor.authorHacıhamdioğlu D.Ö.
dc.contributor.authorElmacı A.M.
dc.contributor.authorAtikel Y.Ö.
dc.contributor.authorDelebe E.ÖÇ.
dc.contributor.authorSever F.L.
dc.contributor.authorGökçe İ.
dc.contributor.authorÖner N.
dc.contributor.authorAkman S.
dc.contributor.authorAksu B.
dc.contributor.authorAtmış B.
dc.contributor.authorYel S.
dc.contributor.authorYılmaz A.
dc.contributor.authorÇelik B.
dc.contributor.authorDursun İ.
dc.contributor.authorAlpay H.
dc.date.accessioned2024-07-22T08:05:27Z
dc.date.available2024-07-22T08:05:27Z
dc.date.issued2021
dc.description.abstractBACKGROUND: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. METHODS: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010-2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. RESULTS: The study sample included 195 patients (88 females, 107 males). The mean age at diagnosis was 39.44 ± 47.25 (0.5-208) months; 82/190 patients (43.2%) were diagnosed incidentally; 46/195 patients (23.6%) had an underlying disease; idiopathic hypercalciuria was detected in 75/195 (38.4%) patients. The most common systemic diseases were distal renal tubular acidosis in 11/46 patients (23.9%), primary hyperoxaluria in 9/46 patients (19.6%) and Bartter syndrome in 7/46 patients (15.3%). After one year of follow-up, NC resolved in 56/159 patients (35.2%) and they all did not have an underlying systemic disease. DISCUSSION: The most common presentation of NC was incidental. Distal renal tubular acidosis and primary hyperoxaluria were the main systemic diseases leading to NC, while hypercalciuria was the most common metabolic risk factor. Nephrocalcinosis was found to remain in most of the patients at a one-year follow-up. It may resolve particularly in patients with no underlying systemic disease.
dc.identifier.DOI-ID10.3906/sag-2103-347
dc.identifier.issn13036165
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13143
dc.language.isoEnglish
dc.publisherNLM (Medline)
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAcidosis, Renal Tubular
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectHypercalciuria
dc.subjectHyperoxaluria, Primary
dc.subjectMale
dc.subjectNephrocalcinosis
dc.subjectRetrospective Studies
dc.subjectTurkey
dc.subjectchild
dc.subjectcomplication
dc.subjectfemale
dc.subjecthuman
dc.subjecthypercalciuria
dc.subjectkidney calcification
dc.subjectkidney tubule acidosis
dc.subjectmale
dc.subjectoxalosis 1
dc.subjectpreschool child
dc.subjectretrospective study
dc.subjectturkey (bird)
dc.titleA nationwide retrospective study in Turkish children with nephrocalcinosis
dc.typeArticle

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