Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: A new disorder of glucose tolerance

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dc.contributor.authorKabaroǧlu C.
dc.contributor.authorErsoy B.
dc.contributor.authorOnur E.
dc.contributor.authorÖzhan B.
dc.contributor.authorErdin S.
dc.contributor.authorVar A.
dc.contributor.authorBayindir O.
dc.contributor.authorDinç G.
dc.date.accessioned2024-07-22T08:18:34Z
dc.date.available2024-07-22T08:18:34Z
dc.date.issued2013
dc.description.abstractWe observed glucose levels >140 mg/dL measured at 30 minutes (min) during an oral glucose tolerance test (OGTT) in some obese patients. We aimed to investigate the significance of this finding by comparing lipid profiles, insulin resistance indices, and systemic inflammatory mediators between obese adolescents with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and elevated glucose levels at 30 min. The study involved 80 obese (body mass index >95th percentile for age and sex) adolescents (48 female, 32 male) between 11 and 16 years of age. Depending on OGTT results, patients were divided into NGT and IGT groups. The third group was recruited from the NGT group as having glucose levels > 140 mg/dL at 30 minutes. Lipid profiles, [interleukin-6 (IL-6)], neopterin, and lipoprotein associated phospholipase A2 (Lp-PLA2)] were assessed. Neopterin and Lp-PLA2 levels were significantly higher in obese adolescents with elevated glucose levels at 30 min. compared with those in both NGT and IGT groups (p=0.013, and 0.004, respectively). In these adolescents, IL-6 levels were significantly higher only than the NGT group (p=0.01). In logistic regression analysis, IL-6, neopterin and Lp-PLA2 levels were detected to be related to high blood glucose levels at 30 min (OR 1.11, p = 0.01; OR 9.03, p=0.013; OR 1.01, p=0.004 respectively). Obese adolescents with elevated glucose levels at 30 min. demonstrated higher inflammatory mediators levels, which were atherosclerotic indicators, than obese adolescents with NGT and IGT. These results suggest that glucose levels >140 mg/dL measured at 30 min during an OGTT may be a new disorder of glucose tolerance in obesity. ©The Japan Endocrine Society.
dc.identifier.DOI-ID10.1507/endocrj.EJ12-0079
dc.identifier.issn13484540
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17365
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subject1-Alkyl-2-acetylglycerophosphocholine Esterase
dc.subjectAdolescent
dc.subjectBlood Glucose
dc.subjectBody Mass Index
dc.subjectChild
dc.subjectFemale
dc.subjectGlucose Intolerance
dc.subjectGlucose Tolerance Test
dc.subjectHumans
dc.subjectHyperglycemia
dc.subjectInflammation Mediators
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectInterleukin-6
dc.subjectLogistic Models
dc.subjectMale
dc.subjectNeopterin
dc.subjectObesity
dc.subjectTurkey
dc.subjectUp-Regulation
dc.subjectC reactive protein
dc.subjectfibrinogen
dc.subjectglucose
dc.subjectinsulin
dc.subjectinterleukin 6
dc.subjectneopterin
dc.subjectphospholipase A2
dc.subjectadolescent
dc.subjectadolescent health
dc.subjectarticle
dc.subjectbiochemical composition
dc.subjectbody mass
dc.subjectchild
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthuman
dc.subjectimpaired glucose tolerance
dc.subjectinsulin resistance
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectobesity
dc.subjectoral glucose tolerance test
dc.subjectschool child
dc.subjectsex ratio
dc.titleElevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: A new disorder of glucose tolerance
dc.typeArticle

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