Anti-acetylcholinesterase, antiprotozoal and cytotoxic activities of some Turkish marine algae

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dc.contributor.authorCinar E.
dc.contributor.authorTaskin E.
dc.contributor.authorTasdemir D.
dc.contributor.authorOzkale E.
dc.contributor.authorGrienke U.
dc.contributor.authorFirsova D.
dc.date.accessioned2024-07-22T08:08:52Z
dc.date.available2024-07-22T08:08:52Z
dc.date.issued2019
dc.description.abstractThe crude (MeOH:CHCl3) and n-hexane-soluble extracts from four brown algae (Phaeophyceae) [Petalonia fascia, Cystoseira crinita, Cystoseira foeniculacea, and Halopteris scoparia], one red alga (Rhodophyta) [Jania rubens] and three green algae (Chlorophyta) [Chaetomorpha aerea, Codium fragile subsp. fragile, and Ulva compressa] from Turkish coasts (Izmir Bay, Ayvalik and Çanakkale) were assessed in vitro for their acetylcholinesterase (AChE) inhibitory activities at 200, 150, 50, 20 μg/mL test concentration with Ellman's method. The crude extract of P. fascia possessed the highest inhibition (IC5 0 value of 19,22±10,47 μg/mL) against AChE. Galanthamine HBr was used as standard drug that gave against AChE enzyme IC5 0 of 3.44±1.14 μM. In the second stage, the crude, hexane-soluble, chloroform-soluble and water-methanol soluble extracts of the marine algae were observed in vitro against parasitic protozoa (Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi ve Leishmania infantum). According to results, the most potent protozoal activities were shown by the Khex of C. crinita (IC5 0 value of 10,62 μg/ml), followed by the Khex of C. fragile subsp. fragile (IC50 value of 11,89 μg/ml). The hekzan-soluble (Khex) and chloroform-soluble (KCH) extracts gave the best results. The marine algae were also tested on MRC-5 cells (human fibroblasts) for by controlling tamoxifen. The extracts of H. scoparia, C. aerea ve C. fragile subsp. fragile showed toxicity. © by PSP
dc.identifier.issn10184619
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14563
dc.language.isoEnglish
dc.publisherParlar Scientific Publications
dc.subjectAyvalik
dc.subjectBalikesir [Turkey]
dc.subjectIzmir Bay
dc.subjectIzmir [Turkey]
dc.subjectTurkey
dc.subjectalgae
dc.subjectChaetomorpha aerea
dc.subjectChlorophyta
dc.subjectCodium fragile
dc.subjectCystoseira crinita
dc.subjectCystoseira foeniculacea
dc.subjectHalopteris scoparia
dc.subjectJania rubens
dc.subjectLeishmania infantum
dc.subjectPetalonia fascia
dc.subjectPhaeophyceae
dc.subjectPlasmodium falciparum
dc.subjectProtozoa
dc.subjectRhodophyta
dc.subjectTrypanosoma brucei brucei
dc.subjectTrypanosoma cruzi
dc.subjectUlva compressa
dc.subjectbrown alga
dc.subjectcell
dc.subjectdrug
dc.subjectinhibition
dc.subjectphytochemistry
dc.subjectplant extract
dc.subjectprotozoan
dc.subjectred alga
dc.subjecttoxicity
dc.titleAnti-acetylcholinesterase, antiprotozoal and cytotoxic activities of some Turkish marine algae
dc.typeArticle

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