Relevance between clinical status and exhaled molecules related to neutrophilic inflammation in pediatric cystic fibrosis

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dc.contributor.authorToprak Kanik E.
dc.contributor.authorYilmaz O.
dc.contributor.authorOzdogru E.
dc.contributor.authorAlper H.
dc.contributor.authorUlman C.
dc.contributor.authorKanik A.
dc.contributor.authorSimsek Y.
dc.contributor.authorYuksel H.
dc.date.accessioned2024-07-22T08:07:11Z
dc.date.available2024-07-22T08:07:11Z
dc.date.issued2020
dc.description.abstractIntroduction: Cystic fibrosis (CF) is characterized with chronic inflammation with neutrophil and related cytokines in airway secretions. We aimed to measure the levels of neutrophil related inflammatory markers as nitric oxide, IL-8, IL-17, leukotriene B4 and neutrophil elastase as well as e-cadherin in exhaled breath condensate (EBC), and to determine their relation with clinical findings. Methods: We consecutively enrolled cystic fibrosis patients into our clinics between the age of six and eighteen years who could cooperate for exhaled breath condensate to this case-control study (n = 30). The age and sex matched control group (n = 26) was enrolled. Spirometry was performed during the stable period and EBC samples were obtained for measurement of the markers. Results: The mean age of the subjects enrolled was 12.1(4.2) years and 40% were positive for P.Aeruginosa in sputum. Subjects who had P.Aeruginosa in sputum cultures had significantly lower FEV1, FVC and FEF 25/75 values compared to the ones without P.Aeruginosa (p = 0.002, p = 0.002 and p = 0.005 respectively). EBC neutrophil elastase levels were significantly higher in the CF patients compared to non-CF controls (3.11 4.71 versus 0.90 2.68, p = 0.04). Nitric oxide, IL-17, IL-8, e-cadherin, neutrophil elastase or leukotriene B4 levels in EBC of CF patients were not related to P.Aeruginosa s infection, FEV1 levels or hospital admission in the last year. Conclusion: In our study, neutrophil elastase levels in EBC are higher in CF patients compared to non-CF controls. This is independent of acute infection and is evidence to the persistence of neutrophilic lung injury. However, EBC NO, IL-8, IL-17, e-cadherin, neutrophil elastase and leukotriene B4 levels as inflammatory markers, are not correlated with disease progression or clinical findings. © 2020 IOP Publishing Ltd.
dc.identifier.DOI-ID10.1088/1752-7163/ab670d
dc.identifier.issn17527155
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13868
dc.language.isoEnglish
dc.publisherInstitute of Physics Publishing
dc.subjectBreath Tests
dc.subjectChild
dc.subjectCystic Fibrosis
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectinterleukin 17
dc.subjectinterleukin 8
dc.subjectleukocyte elastase
dc.subjectleukotriene B4
dc.subjectnitric oxide
dc.subjectuvomorulin
dc.subjectArticle
dc.subjectcase control study
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdisease exacerbation
dc.subjectexpired air
dc.subjectfemale
dc.subjectforced expiratory volume
dc.subjectgroups by age and sex
dc.subjecthospital admission
dc.subjecthuman
dc.subjectinfection
dc.subjectlung fibrosis
dc.subjectmale
dc.subjectneutrophil
dc.subjectpediatric patient
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectPseudomonas infection
dc.subjectrespiratory tract inflammation
dc.subjectschool child
dc.subjectspirometry
dc.subjectsputum analysis
dc.subjectblood
dc.subjectbreath analysis
dc.subjectcystic fibrosis
dc.subjectpathology
dc.subjectprocedures
dc.titleRelevance between clinical status and exhaled molecules related to neutrophilic inflammation in pediatric cystic fibrosis
dc.typeArticle

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