Matrix changes due to the toxic effects of metronidazole in intestinal tissue of fish (Onchorhynchus mykiss)

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dc.contributor.authorGürcü B.
dc.contributor.authorKoca Y.B.
dc.contributor.authorÖzkut M.
dc.contributor.authorTuğlu M.T.
dc.date.accessioned2024-07-22T08:12:07Z
dc.date.available2024-07-22T08:12:07Z
dc.date.issued2016
dc.description.abstractMetranidazole (MTZ) is an antibiotic used for parasitic infections in a number of species. Accumulation of this drug in the environment and its interaction with fish of economic value makes this drug particularly important. In the present study, we examined the histopathological effects of MTZ on the intestinal tissue of Oncorhynchus mykiss.The fish in aquarium were exposed to MTZ at doses of 5, 10, 20 mg/L for 2, 4 and 8 days. At the end of the experiments, macroscopic pathology or death were not observed at these doses. Histochemical staining with Haematoxylene-Eosin, Periodic Acid Schiff and Gomori Trichrome showed, depending on increased dose and prolonged duration, areas of necrosis, edema, inflammation, small tears at the tips of the villi and excretion with heterogenic distribution of the Goblet cells. Moreover, changes in the connective tissue of the intestines due to toxicity of MTZ and decreases in immunostaining of matrix proteins such as laminin and collagen IV, especially in the epithelium were observed.Findings of the present study would be useful to demonstrate the adverse effects of MTZ use, emphasizing the importance of the effect on fish which could be very important public health. © 2015 Elsevier Ltd.
dc.identifier.DOI-ID10.1016/j.chemosphere.2015.10.043
dc.identifier.issn00456535
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15923
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.subjectAnimals
dc.subjectDose-Response Relationship, Drug
dc.subjectEcotoxicology
dc.subjectIntestines
dc.subjectMetronidazole
dc.subjectOncorhynchus mykiss
dc.subjectTime Factors
dc.subjectWater Pollutants, Chemical
dc.subjectOncorhynchus
dc.subjectOncorhynchus mykiss
dc.subjectCell death
dc.subjectCollagen
dc.subjectFish
dc.subjectMusculoskeletal system
dc.subjectPathology
dc.subjectToxicity
dc.subjectcollagen type 4
dc.subjectlaminin
dc.subjectmetronidazole
dc.subjectmetronidazole
dc.subjectwater pollutant
dc.subjectConnective tissues
dc.subjectExtracellular matrices
dc.subjectIntestine
dc.subjectMetronidazole
dc.subjectOnchorhynchus mykiss
dc.subjectantibiotics
dc.subjectchemical pollutant
dc.subjectcollagen
dc.subjectdigestive system
dc.subjecthistopathology
dc.subjectmatrix
dc.subjectsalmonid
dc.subjecttoxicity
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbasement membrane
dc.subjectcell death
dc.subjectcell infiltration
dc.subjectcell nucleus
dc.subjectcollagen fiber
dc.subjectcolumnar epithelium
dc.subjectconnective tissue
dc.subjectcontrolled study
dc.subjectdegeneration
dc.subjectdrug effect
dc.subjectdrug exposure
dc.subjecteukaryotic flagellum
dc.subjectgastrointestinal mucosa
dc.subjectgastrointestinal toxicity
dc.subjectgoblet cell
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectintestinal tissue
dc.subjectintestine necrosis
dc.subjectintestine villus
dc.subjectlamina propria
dc.subjectlymphocyte
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectOncorhynchus mykiss
dc.subjectserosa
dc.subjectsmooth muscle fiber
dc.subjectsubmucosa
dc.subjectanimal
dc.subjectcytology
dc.subjectdose response
dc.subjectdrug effects
dc.subjectecotoxicology
dc.subjectintestine
dc.subjectmetabolism
dc.subjecttime factor
dc.subjecttoxicity
dc.subjectwater pollutant
dc.subjectTissue
dc.titleMatrix changes due to the toxic effects of metronidazole in intestinal tissue of fish (Onchorhynchus mykiss)
dc.typeArticle

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