Possible relations between oxidative damage and apoptosis in benign prostate hyperplasia and prostate cancer patients

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dc.contributor.authorKosova F.
dc.contributor.authorTemeltaş G.
dc.contributor.authorArı Z.
dc.contributor.authorLekili M.
dc.date.accessioned2024-07-22T08:17:14Z
dc.date.available2024-07-22T08:17:14Z
dc.date.issued2014
dc.description.abstractCancer has been described as the twentieth century plague, and is a very common health problem. It has been reported that ROS and ROS products play a key role in cancer and that oxidative damage is effective in apoptosis initiation. In this study we aimed to evaluate the relationship between MDA (malondialdehyde), DNA damage (8-hydroxyguanine, 8-OH-dG), and caspase-3 in BHP and prostate cancer patients. Twenty male patients with prostate cancer and 20 male patients with benign prostate hyperplasia were included into this study. The MDA (nanomole), DNA damage (nanograms per millilitre), and caspase-3 (nanograms per millilitre) levels were measured in prostate cancer and benign prostate hyperplasia using Elisa kits (Millipore Corporation, Billerica, MA, USA). In the prostate cancer group, serum MDA (30.96± 9.25) and DNA damage (4.42±0.36) levels were significantly raised (p <0.05) when compared to the benign prostate hyperplasia group (24.05±8.06, 3.99±0.54). However, in the prostate cancer group, serum caspase-3 (2.36±0.82) levels were statistically significantly lowered (p <0.05) compared with the benign prostate hyperplasia group (3.15±1.04). We observed that altered prooxidant, DNA damage levels may lead to an increase in oxidative damage and may consequently play an important role in prostate carcinogenesis. These findings indicate that, although the triggering of these changes is unknown, changes in the levels of MDA, DNA damage, and caspase-3 in the blood are related to prostatic carcinoma development. In addition, it would be appropriate to conduct new studies with a large number of patients at different stages. © International Society of Oncology and BioMarkers (ISOBM) 2013.
dc.identifier.DOI-ID10.1007/s13277-013-1560-y
dc.identifier.issn10104283
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16995
dc.language.isoEnglish
dc.publisherIOS Press BV
dc.subjectApoptosis
dc.subjectCaspase 3
dc.subjectDNA Damage
dc.subjectHumans
dc.subjectLipid Peroxidation
dc.subjectMale
dc.subjectOxidation-Reduction
dc.subjectProstatic Hyperplasia
dc.subjectProstatic Neoplasms
dc.subject8 hydroxyguanine
dc.subjectcaspase 3
dc.subjectDNA
dc.subjectmalonaldehyde
dc.subjectcaspase 3
dc.subjectapoptosis
dc.subjectarticle
dc.subjectblood sampling
dc.subjectcancer ELISA kit
dc.subjectcancer patient
dc.subjectcarcinogenesis
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectDNA damage
dc.subjectenzyme activation
dc.subjectenzyme blood level
dc.subjecthuman
dc.subjectmale
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectprostate cancer
dc.subjectprostate hypertrophy
dc.subjectblood
dc.subjectDNA damage
dc.subjectlipid peroxidation
dc.subjectmetabolism
dc.subjectoxidation reduction reaction
dc.subjectpathology
dc.subjectprostate hypertrophy
dc.subjectprostate tumor
dc.titlePossible relations between oxidative damage and apoptosis in benign prostate hyperplasia and prostate cancer patients
dc.typeArticle

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