Comparison of the Rate of Induced Intrinsic Pathway of Apoptosis on COLO-320 and COLO-741

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dc.contributor.authorHincal E.
dc.contributor.authorSoykut G.
dc.contributor.authorTijjani Saad F.
dc.contributor.authorVatansever S.
dc.contributor.authorAbdullahi Baba I.
dc.contributor.authorÇalış İ.
dc.contributor.authorKaymakamzade B.
dc.contributor.authorBecer E.
dc.date.accessioned2024-07-22T08:06:42Z
dc.date.available2024-07-22T08:06:42Z
dc.date.issued2021
dc.description.abstractMathematical modeling is a key tool in understanding complicated behavior of large signal transduction networks. In this paper a mathematical model is developed to understand the complex signaling behavior of induced apoptosis in Colo-320 and Colo-741 cell lines. The model studies the intrinsic pathway of apoptosis induced by Apaf-1, Cyt-c, and Caspase 3. Experimentally these tests were carried out five times for three groups; namely Control, DCM and Aqueous groups. The main aim is to compare the rate of the occurrence of apoptosis in the two cells Colo-320 and Colo-741 using experimental data. Numerical results reveal that apoptosis takes place at the same time in DCM for Colo-320 and Colo-741, but slightly faster in Aqueous group for Colo-320. It was observed that it took place between the 5–7th h in all the cases. © 2021, Springer Nature Switzerland AG.
dc.identifier.DOI-ID10.1007/978-3-030-69292-6_12
dc.identifier.issn21941009
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13665
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectCell culture
dc.subjectCell signaling
dc.subjectSignal transduction
dc.subjectCaspase-3
dc.subjectCell lines
dc.subjectInduced apoptosis
dc.subjectLarge-signals
dc.subjectModel study
dc.subjectNumerical results
dc.subjectCell death
dc.titleComparison of the Rate of Induced Intrinsic Pathway of Apoptosis on COLO-320 and COLO-741
dc.typeConference paper

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